Exposure to benzo(a)pyrene from juvenile period to peripubertal impairs male reproductive parameters in adult rats

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dc.contributor.authorJorge, Bárbara Campos [UNESP]
dc.contributor.authorReis, Ana Carolina Casali [UNESP]
dc.contributor.authorSterde, Érika Tissiana [UNESP]
dc.contributor.authorBalin, Paola da Silva [UNESP]
dc.contributor.authorScarano, Wellerson Rodrigo [UNESP]
dc.contributor.authorHisano, Hamilton
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.date.accessioned2021-06-25T10:33:17Z
dc.date.available2021-06-25T10:33:17Z
dc.date.issued2021-01-01
dc.description.abstractBenzo(a)pyrene (BaP) is a persistent organic pollutant and endocrine disruptor that can compromise the steroidogenesis process by interacting with the StAR protein, causing adverse effects on male reproduction. However, consequences of prepubertal BaP exposure and its impacts on adult life are yet unknown. This study investigated the effects of BaP exposure from the juvenile period to peripubertal on reproductive parameters in adult male rats. Males were exposed to 0; 0.1; 1 or 10 μg/kg/day of BaP from post-natal (PND) 23 to PND 53 (by gavage). The lowest dose of BaP was able to compromise the male copulatory behavior, as evidenced by the delay in the first mount, intromission and ejaculation. Furthermore, BaP-treated groups showed lower sperm quality (disrupted motility and morphology) and quantity, reduced relative weights of the thyroid and seminal gland. Serum testosterone levels and the Leydig cells nuclei volume were decreased by BaP exposure whereas the StAR expression was increased. Histopathological changes in the testis also were detected in the males exposed to BaP. These results showed that prepubertal BaP-exposure adversely influenced the male reproductive system in the adult life, indicating that a comprehensive risk assessment of BaP-exposure on prepubertal period is necessary. Prepubertal BaP-exposure compromised reproductive parameters in male rats, causing permanent changes in StAR protein expression in testis.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.description.affiliationEmbrapa Environment
dc.description.affiliationCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.description.affiliationUnespCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2017/22176-4
dc.description.sponsorshipIdFAPESP: 2019/03284-6
dc.identifierhttp://dx.doi.org/10.1016/j.chemosphere.2020.128016
dc.identifier.citationChemosphere, v. 263.
dc.identifier.doi10.1016/j.chemosphere.2020.128016
dc.identifier.issn1879-1298
dc.identifier.issn0045-6535
dc.identifier.scopus2-s2.0-85089800067
dc.identifier.urihttp://hdl.handle.net/11449/206500
dc.language.isoeng
dc.relation.ispartofChemosphere
dc.sourceScopus
dc.subjectEndocrine disruptor
dc.subjectPolycyclic aromatic hydrocarbons
dc.subjectStAR protein
dc.subjectTestosterone levels
dc.titleExposure to benzo(a)pyrene from juvenile period to peripubertal impairs male reproductive parameters in adult ratsen
dc.typeArtigo
unesp.author.orcid0000-0003-4589-2770[4]

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Botucatu - CEATOX - Centro de Assistência Toxicológica