A simple and environmentally friendly reflectometric method for the rapid quantitative analysis of captopril in pharmaceutical formulations

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dc.contributor.authorRibeiro, Paulo Roberto S.
dc.contributor.authorPezza, Leonardo [UNESP]
dc.contributor.authorPezza, Helena Redigolo [UNESP]
dc.contributor.institutionUniversidade Federal do Maranhão (UFMA)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:26:17Z
dc.date.available2014-05-27T11:26:17Z
dc.date.issued2011-12-01
dc.description.abstractThis paper describes a simple, environmentally friendly and rapid quantitative spot test procedure for the determination of captopril (CPT) in bulk drug and in pharmaceutical formulations by using diffuse reflectance spectroscopy. The proposed method is based on the reflectance measurements of the orange compound (λ max 490 nm) produced by the spot test reaction between CPT and p-chloranil (CL). Under optimal conditions, calibration curves were obtained for CPT by plotting the optical density of the reflectance signal (A R) vs. the log of the mol L -1 concentration, from 6.91×10 -3 to 1.17×10 -1, with a good coefficient of determination (R 2 = 0.9992). The common excipients used as additives in pharmaceuticals do not interfere in the proposed method. The method was applied to determine CPT in commercial pharmaceutical formulations. The results obtained by the proposed method are compared favorably with those obtained by an official procedure at 95% confidence level. The method validation results showed that the sensitivity and selectivity of the methods were adequated for drug monitoring in industrial quality control laboratories. © 2011 Moment Publication.en
dc.description.affiliationCentro de Ciências Sociais, Saúde e Tecnologia UFMA, CEP 65900-000, Imperatriz, MA
dc.description.affiliationInstituto de Química UNESP, P.O. Box 355, CEP 14801-970, Araraquara, SP
dc.description.affiliationUnespInstituto de Química UNESP, P.O. Box 355, CEP 14801-970, Araraquara, SP
dc.format.extent91-103
dc.identifierhttp://www.eurasianjournals.com/index.php/ejac/article/view/345
dc.identifier.citationEurasian Journal of Analytical Chemistry, v. 6, n. 2, p. 91-103, 2011.
dc.identifier.file2-s2.0-84855173051.pdf
dc.identifier.issn1306-3057
dc.identifier.lattes5978908591853524
dc.identifier.lattes3192125098361121
dc.identifier.orcid0000-0003-0197-7369
dc.identifier.scopus2-s2.0-84855173051
dc.identifier.urihttp://hdl.handle.net/11449/72976
dc.language.isoeng
dc.relation.ispartofEurasian Journal of Analytical Chemistry
dc.relation.ispartofsjr0,160
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCaptopril
dc.subjectCharge transfer complex
dc.subjectDiffuse reflectance
dc.subjectPharmaceutical formulations
dc.subjectcaptopril
dc.subjectchloranil
dc.subjectexcipient
dc.subjectchemical reaction
dc.subjectcontrolled study
dc.subjectdiffuse reflectance spectroscopy
dc.subjectgreen chemistry
dc.subjectoptical density
dc.subjectquality control
dc.subjectquantitative analysis
dc.subjectsensitivity analysis
dc.titleA simple and environmentally friendly reflectometric method for the rapid quantitative analysis of captopril in pharmaceutical formulationsen
dc.typeArtigo
dcterms.licensehttp://www.eurasianjournals.com/index.php/ejac/about/editorialPolicies#openAccessPolicy
unesp.author.lattes5978908591853524
unesp.author.lattes3192125098361121
unesp.author.orcid0000-0003-0197-7369[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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