Obesogenic environment by excess of dietary fats in different phases of development reduces spermatic efficiency of wistar rats at adulthood: correlations with metabolic status

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dc.contributor.authorReame, Vanessa [UNESP]
dc.contributor.authorPytlowanciv, Eloisa Zanin [UNESP]
dc.contributor.authorRibeiro, Daniele Lisboa
dc.contributor.authorPissolato, Thiago Feres [UNESP]
dc.contributor.authorTaboga, Sebastiao Roberto [UNESP]
dc.contributor.authorGoes, Rejane Maira [UNESP]
dc.contributor.authorPinto-Fochi, Maria Etelvina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-04-27T11:56:06Z
dc.date.available2015-04-27T11:56:06Z
dc.date.issued2014
dc.description.abstractThis study compares the impact of obesogenic environment (OE) in six different periods of development on sperm parameters and the testicular structure of adult rats and their correlations with sex steroid and metabolic scenario. Wistar rats were exposed to OE during gestation (O1), during gestation/lactation (O2), from weaning to adulthood (O3), from lactation to adulthood (O4), from gestation to sexual maturity (O5), and after sexual maturation (O6). OE was induced by a 20% fat diet, and control groups were fed a balanced diet (4% fat). Serum leptin levels and adiposity index indicate that all groups were obese, except for O1. Three progressive levels of impaired metabolic status were observed: O1 presented insulin resistance, O2 were insulin resistant and obese, and groups O3, O4, and O5 were insulin resistant, obese, and diabetic. These three levels of metabolic damage were proportional to the increase of leptin and decreased circulating testosterone. The impairment in the daily sperm production (DSP) paralleled these three levels of metabolic and hormonal damage being marginal in O1, increasing in O2, and being higher in groups O3, O4, O5, and O6. None of the OE periods affected the sperm transit time in the epididymis, and the lower sperm reserves were caused mainly by impaired DSP. In conclusion, OE during sexual maturation markedly reduces the DSP at adulthood in the rat. A severe reduction in the DSP also occurs in OE exposure during gestation/lactation but not in gestation, indicating that breast-feeding is a critical period for spermatogenic impairment under obesogenic conditions.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, Sao Jose do Rio Preto, Rua Cristovão Colombo 2265, Jardim Nazareth, CEP 15054-000, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, Sao Jose do Rio Preto, Rua Cristovão Colombo 2265, Jardim Nazareth, CEP 15054-000, SP, Brasil
dc.description.affiliationUnespDepartment of Structural and Functional Biology, Institute of Biology, State University of Campinas, UNICAMP, Campinas, São Paulo, Brazi
dc.description.affiliationUnespDepartment of Histology, Institute of Biomedical Sciences, Federal University of Uberlandia - UFU, Uberlândia, Minas Gerais, Brazil
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25339108
dc.identifier.citationBiology of Reproduction, 2014.
dc.identifier.doi10.1095/biolreprod.114.121962
dc.identifier.issn0006-3363
dc.identifier.lattes1445259468526188
dc.identifier.lattes9698639603340231
dc.identifier.lattes0947193347312157
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.orcid0000-0002-3622-460X
dc.identifier.urihttp://hdl.handle.net/11449/122854
dc.language.isopor
dc.relation.ispartofBiology of Reproduction
dc.relation.ispartofjcr3.184
dc.relation.ispartofsjr1,446
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.titleObesogenic environment by excess of dietary fats in different phases of development reduces spermatic efficiency of wistar rats at adulthood: correlations with metabolic statusen
dc.typeArtigo
unesp.author.lattes1445259468526188
unesp.author.lattes9698639603340231
unesp.author.lattes0947193347312157[6]
unesp.author.orcid0000-0002-0970-4288[5]
unesp.author.orcid0000-0002-3622-460X[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentBiologiapt

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