Retinoids for prevention and treatment of actinic keratosis

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dc.contributor.authorIanhez, Mayra
dc.contributor.authorMiot, Hélio Amante [UNESP]
dc.contributor.authorFroes Fleury Junior, Luiz Fernando
dc.contributor.authorBagatin, Edileia
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-12-03T13:08:41Z
dc.date.available2014-12-03T13:08:41Z
dc.date.issued2013-07-01
dc.description.abstractActinic keratosis is a common cause of dermatological consultations and it presents a strong association with squamous cell carcinoma. Many substances are used for treatment and prevention, such as retinoids. Nevertheless, many studies on retinoids emphasize their application in treating and preventing non melanoma skin cancers. In this article, we reviewed studies about systemic and topical retinoids used with immunocompetent patients and organ transplant recipients with actinic keratosis, as primary or secondary outcomes. The majority of these papers pointed to a reduction in actinic keratosis count after treatment with retinoids. However, studies need to be better-defined in order to address the lack of a standardized dose, the absence of control groups, the low number of patients and short follow-up periods. Blind, randomized and controlled clinical trials with adequate sample sizes, specifically focused on actinic keratosis, are needed to clarify the real benefit of topical and/or oral retinoids. Comparison of efficacy and safety between oral and topical retinoids in the prevention and treatment of non-melanoma skin cancers and actinic keratosis is an essential pre requisite to establish new strategies to control these conditions.en
dc.description.affiliationFed Univ Goias UFGO, Sao Paulo, Brazil
dc.description.affiliationSao Paulo State Univ Julio de Mesquita Filho UNES, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo EPM UNIFESP, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ Julio de Mesquita Filho UNES, Sao Paulo, Brazil
dc.format.extent585-593
dc.identifierhttp://dx.doi.org/10.1590/abd1806-4841.20131803
dc.identifier.citationAnais Brasileiros De Dermatologia. Rio De Janeiro Rj: Soc Brasileira Dermatologia, v. 88, n. 4, p. 585-593, 2013.
dc.identifier.doi10.1590/abd1806-4841.20131803
dc.identifier.fileS0365-05962013000400585.pdf
dc.identifier.issn0365-0596
dc.identifier.lattes2543633050941005
dc.identifier.scieloS0365-05962013000400585
dc.identifier.urihttp://hdl.handle.net/11449/111485
dc.identifier.wosWOS:000324929100012
dc.language.isoeng
dc.publisherSoc Brasileira Dermatologia
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.relation.ispartofjcr0.884
dc.relation.ispartofsjr0,520
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectChemopreventionen
dc.subjectIsotretinoinen
dc.subjectKeratosis, Actinicen
dc.subjectRetinoidsen
dc.subjectTretinoinen
dc.titleRetinoids for prevention and treatment of actinic keratosisen
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Dermatologia
unesp.author.lattes2543633050941005
unesp.author.orcid0000-0001-7190-8241[4]
unesp.author.orcid0000-0002-2596-9294[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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