Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats

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dc.contributor.authorChaguri, Joao Leandro [UNESP]
dc.contributor.authorGodinho, Antonio Francisco [UNESP]
dc.contributor.authorHorta, Daniel França [UNESP]
dc.contributor.authorGonçalves-Rizzi, Victor Hugo [UNESP]
dc.contributor.authorPossomato-Vieira, Jose Sergio [UNESP]
dc.contributor.authorNascimento, Regina Aparecida [UNESP]
dc.contributor.authorDias-Junior, Carlos Alan [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:00:36Z
dc.date.available2018-12-11T17:00:36Z
dc.date.issued2016-03-01
dc.description.abstractRecent reports show that fipronil affects non-target organisms, including environmental species populations and potentially humans. We aimed to examine if fipronil exposure affects the systolic blood pressure and related biomarkers. Thus, fipronil was orally administered to rats (30 mg/kg/day) during 15 days (Fipronil group) or physiological solution (Control group). While fipronil increased significantly the systolic blood pressure (158 ± 13 mmHg), no significant changes were observed in Control group (127 ± 3 mmHg). Significantly, higher levels of fipronil in plasma were observed in Fipronil group (0.46 ± 0.09 μg/mL versus 0.17 ± 0.11 μg/mL in Control group). Fipronil group showed lower weight gain compared with Control group. While fipronil resulted in higher concentrations of endothelin-1, reduced antioxidant capacity and lower levels of circulating matrix metalloproteinase 2 (MMP-2) and nitric oxide (NO) metabolites compared to Control group, no alteration was observed in serum biomarkers of renal and hepatic/biliary functional abilities. Therefore, this study suggests that fipronil causes hypertension and endothelin-1 plays a key role. Also, these findings suggest that reductions of both MMP-2 and NO may contribute with the elevation of systolic blood pressure observed with fipronil.en
dc.description.affiliationCenter for Toxicological Assistance Biosciences Institute of Botucatu Sao Paulo State University - UNESP
dc.description.affiliationDepartment of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University - UNESP
dc.description.affiliationUnespCenter for Toxicological Assistance Biosciences Institute of Botucatu Sao Paulo State University - UNESP
dc.description.affiliationUnespDepartment of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University - UNESP
dc.format.extent63-68
dc.identifierhttp://dx.doi.org/10.1016/j.etap.2015.12.020
dc.identifier.citationEnvironmental Toxicology and Pharmacology, v. 42, p. 63-68.
dc.identifier.doi10.1016/j.etap.2015.12.020
dc.identifier.file2-s2.0-84956676416.pdf
dc.identifier.issn1872-7077
dc.identifier.issn1382-6689
dc.identifier.scopus2-s2.0-84956676416
dc.identifier.urihttp://hdl.handle.net/11449/172485
dc.language.isoeng
dc.relation.ispartofEnvironmental Toxicology and Pharmacology
dc.relation.ispartofsjr0,813
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBiomarkers
dc.subjectCardiovascular toxicity
dc.subjectFipronil
dc.subjectPesticides
dc.titleExposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of ratsen
dc.typeArtigo
unesp.author.lattes9719891659222257[2]
unesp.author.lattes6296664642422599[7]
unesp.author.orcid0000-0002-0348-6144[7]
unesp.author.orcid0000-0002-2832-8919[2]

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Botucatu - CEATOX - Centro de Assistência Toxicológica
Artigos - Farmacologia - IBB