An environmentally friendly reflectometric method for ranitidine determination in pharmaceuticals and human urine

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dc.contributor.authorLima, Liliane Spazzapam [UNESP]
dc.contributor.authorWeinert, Patricia Los [UNESP]
dc.contributor.authorLemos, Sahra Cavalcante [UNESP]
dc.contributor.authorSequinel, Rodrigo [UNESP]
dc.contributor.authorPezza, Helena Redigolo [UNESP]
dc.contributor.authorPezza, Leonardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:19:03Z
dc.date.available2014-05-20T14:19:03Z
dc.date.issued2009-01-01
dc.description.abstractThis paper describes an environmentally friendly method for quantitative determination of ranitidine using diffuse reflectance spectroscopy. This method is based on the reflectance measurements of the colored product produced from the spot test reaction between ranitidine and p-dimethylaminocinnamaldehyde (p-DAC), in acid medium, using filter paper as solid support. Experimental design methodologies were used to optimize the optimal conditions. All reflectance measurements were carried out at 590 nm and the linear range was from 1.42 x 10(-3) to 3.42 x 10(-2) mol L(-1), with a correlation coefficient of 0.997. The limit of detection was estimated to be 1.09 x 10(-3) mol L(-1) (R.S.D. = 1.9%). The proposed method was successfully applied to the determination of ranitidine in commercial brands of pharmaceuticals and no interferences were observed from the common excipients in formulations. The results obtained by the proposed method were favorably compared with those obtained by an official procedure at 95% confidence level. Additionally, the method was also applied to the determination of ranitidine in human urine showing excellent recoveries (99.6-100.3%). (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1999-2004
dc.identifierhttp://dx.doi.org/10.1016/j.saa.2008.07.036
dc.identifier.citationSpectrochimica Acta Part A-molecular and Biomolecular Spectroscopy. Oxford: Pergamon-Elsevier B.V. Ltd, v. 71, n. 5, p. 1999-2004, 2009.
dc.identifier.doi10.1016/j.saa.2008.07.036
dc.identifier.issn1386-1425
dc.identifier.lattes3192125098361121
dc.identifier.lattes5978908591853524
dc.identifier.orcid0000-0003-0197-7369
dc.identifier.urihttp://hdl.handle.net/11449/25737
dc.identifier.wosWOS:000261900000062
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
dc.relation.ispartofjcr2.880
dc.relation.ispartofsjr0,648
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectRanitidineen
dc.subjectDiffuse reflectance spectroscopyen
dc.subjectSpot testen
dc.subjectPharmaceuticalsen
dc.subjectHuman urineen
dc.titleAn environmentally friendly reflectometric method for ranitidine determination in pharmaceuticals and human urineen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes3192125098361121
unesp.author.lattes5978908591853524
unesp.author.orcid0000-0003-0197-7369[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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