Sodium nitrite attenuates hypertension-in-pregnancy and blunts increases in soluble fms-like tyrosine kinase-1 and in vascular endothelial growth factor

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dc.contributor.authorGonçalves-Rizzi, Victor Hugo [UNESP]
dc.contributor.authorPossomato-Vieira, Jose Sergio [UNESP]
dc.contributor.authorSales Graça, Tamiris Uracs [UNESP]
dc.contributor.authorNascimento, Regina Aparecida [UNESP]
dc.contributor.authorDias-Junior, Carlos A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:02:58Z
dc.date.available2018-12-11T17:02:58Z
dc.date.issued2016-07-01
dc.description.abstractPreeclampsia is a pregnancy-associated disorder characterized by hypertension with uncertain pathogenesis. Increases in antiangiogenic soluble fms-like tyrosine kinase-1 (sFlt-1) and reductions in nitric oxide (NO) bioavailability have been observed in preeclamptic women. However, the specific mechanisms linking these detrimental changes to the hypertension-in-pregnancy are not clearly understood. In this regard, while recent findings have suggested that nitrite-derived NO formation exerts antihypertensive and antioxidant effects, no previous study has examined these responses to orally administered nitrite in hypertension-in-pregnancy. We then hypothesized restoring NO bioavailability with sodium nitrite in pregnant rats upon NO synthesis inhibition with N(omega)-nitro-l-arginine methyl ester (L-NAME) attenuates hypertension and high circulating levels of sFlt-1. Number and weight of pups and placentae were recorded to assess maternal-fetal interface. Plasma sFlt-1, vascular endothelial growth factor (VEGF) and biochemical determinants of NO formation and of antioxidant function were measured. We found that sodium nitrite blunts the hypertension-in-pregnancy and restores the NO bioavailability, and concomitantly prevents the L-NAME-induced high circulating sFlt-1 and VEGF levels. Also, our results suggest that nitrite-derived NO protected against reductions in litter size and placental weight caused by L-NAME, improving number of viable and resorbed fetuses and antioxidant function. Therefore, the present findings are consistent with the hypothesis that nitrite-derived NO may possibly be the driving force behind the maternal and fetal beneficial effects observed with sodium nitrite during hypertension-in-pregnancy. Certainly further investigations are required in preeclampsia, since counteracting the damages to the mother and fetal sides resulting from hypertension and elevated sFlt-1 levels may provide a great benefit in this gestational hypertensive disease.en
dc.description.affiliationDepartment of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University (UNESP), Distrito de Rubiao Junior, S/N
dc.description.affiliationUnespDepartment of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University (UNESP), Distrito de Rubiao Junior, S/N
dc.format.extent71-78
dc.identifierhttp://dx.doi.org/10.1016/j.niox.2016.05.004
dc.identifier.citationNitric Oxide - Biology and Chemistry, v. 57, p. 71-78.
dc.identifier.doi10.1016/j.niox.2016.05.004
dc.identifier.file2-s2.0-84969776534.pdf
dc.identifier.issn1089-8611
dc.identifier.issn1089-8603
dc.identifier.scopus2-s2.0-84969776534
dc.identifier.urihttp://hdl.handle.net/11449/172978
dc.language.isoeng
dc.relation.ispartofNitric Oxide - Biology and Chemistry
dc.relation.ispartofsjr1,278
dc.relation.ispartofsjr1,278
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectHypertension-in-pregnancy
dc.subjectN(G)-nitro-l-arginine methyl ester
dc.subjectRats
dc.subjectSodium nitrite
dc.titleSodium nitrite attenuates hypertension-in-pregnancy and blunts increases in soluble fms-like tyrosine kinase-1 and in vascular endothelial growth factoren
dc.typeArtigo
unesp.author.lattes6296664642422599[5]
unesp.author.orcid0000-0002-0348-6144[5]

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