Panacea within a Pandora's box: the antiparasitic effects of phospholipases A2 (PLA2s) from snake venoms

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dc.contributor.authorTeixeira, Samuel Cota
dc.contributor.authorda Silva, Marcelo Santos [UNESP]
dc.contributor.authorGomes, Antoniel Augusto Severo
dc.contributor.authorMoretti, Nilmar Silvio
dc.contributor.authorLopes, Daiana Silva
dc.contributor.authorFerro, Eloisa Amália Vieira
dc.contributor.authorRodrigues, Veridiana de Melo
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversité de Montpellier
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.date.accessioned2022-04-29T08:45:38Z
dc.date.available2022-04-29T08:45:38Z
dc.date.issued2022-01-01
dc.description.abstractParasitic diseases affect millions of individuals worldwide, mainly in low-income regions. There is no cure for most of these diseases, and the treatment relies on drugs that have side effects and lead to drug resistance, emphasizing the urgency to find new treatments. Snake venom has been gaining prominence as a rich source of molecules with antiparasitic potentials, such as phospholipases A2 (PLA2s). Here, we compile the findings involving PLA2s with antiparasitic activities against helminths, Plasmodium, Toxoplasma, and trypanosomatids. We indicate their molecular features, highlighting the possible antiparasitic mechanisms of action of these proteins. We also demonstrate interactions between PLA2s and some parasite membrane components, shedding light on potential targets for drug design that may provide better treatment for the illnesses caused by parasites.en
dc.description.affiliationDepartment of Immunology Institute of Biomedical Science Federal University of Uberlândia
dc.description.affiliationDNA Replication and Repair Laboratory (DRRL) Department of Chemical and Biological Sciences Biosciences Institute São Paulo State University (UNESP)
dc.description.affiliationIBMM CNRS ENSCM Faculté de Pharmacie Université de Montpellier
dc.description.affiliationLaboratório de Biologia Molecular de Patógenos (LBMP) Departamento de Microbiologia Imunologia e Parasitologia Escola Paulista de Medicina Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliationMultidisciplinary Institute of Health Anísio Teixeira Campus Federal University of Bahia (UFBA)
dc.description.affiliationLaboratory of Biochemistry and Animal Toxins Institute of Biotechnology Federal University of Uberlândia (UFU)
dc.description.affiliationUnespDNA Replication and Repair Laboratory (DRRL) Department of Chemical and Biological Sciences Biosciences Institute São Paulo State University (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipIdFAPESP: 2018/09948-0
dc.description.sponsorshipIdFAPESP: 2019/10753-2
dc.description.sponsorshipIdFAPESP: 2020/10277-3
dc.description.sponsorshipIdCNPq: 424729/2018-0
dc.description.sponsorshipIdFAPEMIG: CBB – APQ-01401-17
dc.format.extent80-94
dc.identifierhttp://dx.doi.org/10.1016/j.pt.2021.07.004
dc.identifier.citationTrends in Parasitology, v. 38, n. 1, p. 80-94, 2022.
dc.identifier.doi10.1016/j.pt.2021.07.004
dc.identifier.issn1471-5007
dc.identifier.issn1471-4922
dc.identifier.scopus2-s2.0-85111991738
dc.identifier.urihttp://hdl.handle.net/11449/231489
dc.language.isoeng
dc.relation.ispartofTrends in Parasitology
dc.sourceScopus
dc.subjectantiparasitic drugs
dc.subjectChagas' disease
dc.subjectleishmaniasis
dc.subjectmalaria
dc.subjectphospholipases A2
dc.subjectschistosomiasis
dc.subjectsnake venom
dc.subjectstrongyloidiasis
dc.subjecttoxoplasmosis
dc.titlePanacea within a Pandora's box: the antiparasitic effects of phospholipases A2 (PLA2s) from snake venomsen
dc.typeResenha
unesp.author.orcid0000-0002-1978-1658[1]
unesp.author.orcid0000-0003-4203-9299[2]
unesp.author.orcid0000-0002-1278-7838[3]
unesp.author.orcid0000-0003-0455-2497[4]
unesp.author.orcid0000-0002-2462-4163[5]
unesp.author.orcid0000-0002-7447-2583[6]
unesp.author.orcid0000-0002-3386-9197[7]

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