Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis

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dc.contributor.authorMarques, Ana Paula C.
dc.contributor.authorOliveira, Sandra Maria V. L.
dc.contributor.authorRezende, Grazielli R.
dc.contributor.authorMelo, Dayane A.
dc.contributor.authorFernandes-Fitts, Sonia M.
dc.contributor.authorPontes, Elenir Rose J. C.
dc.contributor.authorBonecini-Almeida, Maria da Gloria
dc.contributor.authorCamargo, Zoilo P.
dc.contributor.authorMendes, Rinaldo P. [UNESP]
dc.contributor.authorPaniago, Anamaria M. M.
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.institutionFundacao Oswaldo Cruz
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T17:40:32Z
dc.date.available2018-11-26T17:40:32Z
dc.date.issued2017-10-01
dc.description.abstractWe estimated the occurrence rate of the booster phenomenon by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis in the central-west region of Brazil. Individuals who had a negative result on a survey performed by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis underwent a second intradermal test after 10-15 days to determine the presence or absence of the booster phenomenon. Statistical analyses were performed using the Chi-square test, Chi-square for linear trend test, Student's t test, and binomial test; p < 0.05 was considered significant. For the first time, we reported the occurrence of the booster phenomenon to an intradermal reaction caused by 43 kDa glycoprotein at a rate of 5.8-8.4%, depending on the test's cutoff point. This suggests that a cutoff point should be considered for the booster phenomenon in intradermal tests with 43 kDa glycoprotein: a difference of 6-7 mm between readings according to the first and second tests, depending on the purpose of the evaluation. The results indicate that the prevalence of paracoccidioidal infection in endemic areas is underestimated, as the booster phenomenon has not been considered in epidemiological surveys for this infection.en
dc.description.affiliationUniv Fed Mato Grosso do Sul, Fac Med, Cidade Univ S-N, BR-79070900 Campo Grande, Brazil
dc.description.affiliationFundacao Oswaldo Cruz, Evandro Chagas Clin Res Inst, Lab Immunol & Immunogenet, BR-21040360 Rio De Janeiro, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Fac Med, Clin Hosp, Med Mycol Lab, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, Dept Trop Dis, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Botucatu, Dept Trop Dis, Botucatu, SP, Brazil
dc.description.sponsorshipHealth Department of the Municipality of Jaraguari (Mato Grosso do Sul, Brazil)
dc.description.sponsorshipPost-Graduation Program for Health and Development of the Central-West Region Brazil
dc.format.extent809-817
dc.identifierhttp://dx.doi.org/10.1007/s11046-017-0159-z
dc.identifier.citationMycopathologia. Dordrecht: Springer, v. 182, n. 9-10, p. 809-817, 2017.
dc.identifier.doi10.1007/s11046-017-0159-z
dc.identifier.fileWOS000409494400004.pdf
dc.identifier.issn0301-486X
dc.identifier.urihttp://hdl.handle.net/11449/163215
dc.identifier.wosWOS:000409494400004
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofMycopathologia
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectParacoccidioidic infection
dc.subjectBooster phenomenon
dc.subjectIntradermal tests
dc.subjectParacoccidioides brasiliensis
dc.subjectParacoccidioidomycosis
dc.subjectgp43
dc.titleStandardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosisen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer

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