Behavioral and neuroendocrine effects of the exposure to chronic restraint or variable stress in early adolescent rats

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dc.contributor.authorCruz, Fabio C. [UNESP]
dc.contributor.authorMarin, Marcelo Tadeu [UNESP]
dc.contributor.authorLeao, Rodrigo M. [UNESP]
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:25:34Z
dc.date.available2014-05-20T13:25:34Z
dc.date.issued2012-02-01
dc.description.abstractStress events during adolescence may contribute to the expression or exacerbation of physical and behavioral disorders. However, little attention has been given to the physiological and behavioral changes promoted by stress during this period of ontogeny. In the present study we investigated, in adolescent male rats, the effects of repeated exposure to restraint or variable stress on: (a) locomotor activity and corticosterone levels after exposure to a novel environment; (b) corticosterone levels in response to the exposure to restraint stress; and (c) changes in body, thymus and adrenal weights. The results demonstrated that repeated exposure to restraint or variable stress reduced the locomotor response, but did not affect corticosterone secretion, in response to a novel environment. Moreover, both chronic stress procedures did not change corticosterone secretion in response to acute restraint stress. Furthermore, our results showed that repeated restraint, but not variable stress, produced a decrease in body weight along the stress exposure. Finally, we observed that the exposure to variable stress reduced the thymus relative weight. Taken together our results suggest that behavioral and physiological changes induced by exposure to chronic stress during adolescence depend on the stress regimen. (C) 2011 ISDN. Published by Elsevier Ltd. All rights reserved.en
dc.description.affiliationSão Paulo Univ Estadual São Paulo UNESP, Pharmacol Lab, Sch Pharmaceut Sci, BR-14801902 São Paulo, Brazil
dc.description.affiliationJoint Grad Program Physiol Sci UFSCar UNESP, BR-13565905 São Paulo, Brazil
dc.description.affiliationFac Odontol Araraquara, BR-14801903 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo Univ Estadual São Paulo UNESP, Pharmacol Lab, Sch Pharmaceut Sci, BR-14801902 São Paulo, Brazil
dc.description.affiliationUnespJoint Grad Program Physiol Sci UFSCar UNESP, BR-13565905 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent19-23
dc.identifierhttp://dx.doi.org/10.1016/j.ijdevneu.2011.10.005
dc.identifier.citationInternational Journal of Developmental Neuroscience. Oxford: Pergamon-Elsevier B.V. Ltd, v. 30, n. 1, p. 19-23, 2012.
dc.identifier.doi10.1016/j.ijdevneu.2011.10.005
dc.identifier.issn0736-5748
dc.identifier.lattes2514762545280942
dc.identifier.lattes7920438802539727
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.urihttp://hdl.handle.net/11449/8116
dc.identifier.wosWOS:000299982500003
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofInternational Journal of Developmental Neuroscience
dc.relation.ispartofjcr2.495
dc.relation.ispartofsjr0,986
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectRestraint stressen
dc.subjectVariable stressen
dc.subjectCorticosteroneen
dc.subjectLocomotionen
dc.subjectNoveltyen
dc.titleBehavioral and neuroendocrine effects of the exposure to chronic restraint or variable stress in early adolescent ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes7920438802539727
unesp.author.lattes2514762545280942[4]
unesp.author.orcid0000-0002-1378-6327[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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