Anti-inflammatory and toxicological evaluation of essential oil from Piper glabratum leaves

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dc.contributor.authorBranquinho, Lidiane Schultz
dc.contributor.authorSantos, Joyce Alencar
dc.contributor.authorCardoso, Claudia Andrea Lima
dc.contributor.authorMota, Jonas da Silva
dc.contributor.authorJunior, Ubirajara Lanza
dc.contributor.authorKassuya, Cândida Aparecida Leite
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.institutionFederal University of Grande Dourados
dc.contributor.institutionUniversidade Estadual de Mato Grosso do Sul (UEMS)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:09:31Z
dc.date.available2018-12-11T17:09:31Z
dc.date.issued2017-02-23
dc.description.abstractEthnopharmacological relevance Although some of the species of the genus Piper exhibit interesting biological properties, studies on Piper glabratum Kunth are very limited. Aim of the study This study investigated the anti-inflammatory activity and the toxicological profile of the essential oil from P. glabratum leaves (OEPG) in mice. Materials and Methods The acute toxicity of OEPG was evaluated by oral administration to female mice as single doses of 500, 1000, 2000 or 5000 mg/kg/body weight. In the subacute toxicity test, the females received 500 or 1000 mg/kg/body weight of OEPG for 28 days. The anti-inflammatory potential of OEPG was evaluated using four models including pleurisy, edema, mechanical hyperalgesia and cold allodynia models in mouse paws. Results No clinical signs of toxicity were observed in animals after acute treatment, which suggested that the LD50 is greater than 5000 mg/kg. The subacute exposure to OEPG produced no significant changes in the hematological or biochemical parameters. Similarly, the histology of the organs and the estrus cycle displayed no marked alterations. OEPG exhibited anti-inflammatory activity as indicated by inhibition of the leukocyte migration (100, 300, 700 mg/kg) and the protein extravasation into the pleural exudates (700 mg/kg). After intraplantar injection of carrageenan, it was observed that the 700 mg/kg dose of OEPG reduced edema formation and decreased the sensitivity to mechanical stimulation and cold. Conclusions These results demonstrate the anti-inflammatory potential of the essential oil of P. glabratum leaves in the absence of toxicity in female mice.en
dc.description.affiliationSchool of Health Sciences Federal University of Grande Dourados
dc.description.affiliationMato Grosso do Sul State University (UEMS)
dc.description.affiliationDepartment of Morphology Institute of Biosciences of Botucatu UNESP – Univ. Estadual Paulista
dc.description.affiliationUnespDepartment of Morphology Institute of Biosciences of Botucatu UNESP – Univ. Estadual Paulista
dc.format.extent372-378
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2017.01.008
dc.identifier.citationJournal of Ethnopharmacology, v. 198, p. 372-378.
dc.identifier.doi10.1016/j.jep.2017.01.008
dc.identifier.issn1872-7573
dc.identifier.issn0378-8741
dc.identifier.scopus2-s2.0-85010880298
dc.identifier.urihttp://hdl.handle.net/11449/174140
dc.language.isoeng
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCarrageenan
dc.subjectEssential oil
dc.subjectInflammation
dc.subjectPiper glabratum
dc.subjectToxicity
dc.titleAnti-inflammatory and toxicological evaluation of essential oil from Piper glabratum leavesen
dc.typeArtigo
unesp.author.lattes0729220781785349[7]
unesp.author.orcid0000-0002-2373-9399[7]

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