Antitumor properties of Ganoderma lucidum polysaccharides and terpenoids

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dc.contributor.authorCamargo, Marcela R. [UNESP]
dc.contributor.authorKaneno, Ramon [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:26:12Z
dc.date.available2014-05-27T11:26:12Z
dc.date.issued2011-12-01
dc.description.abstractGanoderma lucidum is an edible medicinal mushroom with immunomodulatory and antitumor properties, which are mainly attributed to polysaccharides and triterpenes that can be isolated from mycelia, fruiting bodies and spores. G. lucidum has been us d in a powdered form, as a medicinal beverage and a nutraceutical food (usually dried). In the present review we report some historical facts and the experimental evidence that polysaccharides and triterpenes obtained from this mushroom present potential antitumor activity. Direct effects on tumor cells include induction of apoptosis and interference in the cell cycle, whereas indirect effects are based on the modulation of immune response, usually impaired by cancer cells. Data indicate that G. lucidum can be used as a complementary tool for treatment of cancer patients. © by São Paulo State University.en
dc.description.affiliationDepartment of Microbiology and Immunology Institute of Biosciences Universidade Estadual Paulista, Botucatu, SP
dc.description.affiliationDepartment of Pathology School of Medicine Universidade Estadual Paulista, Botucatu, SP
dc.description.affiliationUnespDepartment of Microbiology and Immunology Institute of Biosciences Universidade Estadual Paulista, Botucatu, SP
dc.description.affiliationUnespDepartment of Pathology School of Medicine Universidade Estadual Paulista, Botucatu, SP
dc.format.extent1-8
dc.identifierhttp://arbs.biblioteca.unesp.br/index.php/arbs/article/view/174/155
dc.identifier.citationAnnual Review of Biomedical Sciences, v. 13, p. 1-8.
dc.identifier.file2-s2.0-84856297897.pdf
dc.identifier.issn1806-8774
dc.identifier.lattes8845835550637809
dc.identifier.orcid0000-0002-4292-3298
dc.identifier.scopus2-s2.0-84856297897
dc.identifier.urihttp://hdl.handle.net/11449/72819
dc.language.isoeng
dc.relation.ispartofAnnual Review of Biomedical Sciences
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectImmunomodulation
dc.subjectMushroom
dc.subjectPolysaccharides
dc.subjectTriterpenes
dc.subjectTumor
dc.subjectcaspase
dc.subjectgamma interferon
dc.subjectganoderic acid
dc.subjectGanoderma lucidum extract
dc.subjectGanoderma lucidum polysaccharide
dc.subjectganodermanontriol
dc.subjectinterleukin 10
dc.subjectinterleukin 12
dc.subjectpolysaccharide
dc.subjectprotein Bax
dc.subjectprotein bcl 2
dc.subjectprotein Bid
dc.subjectreactive oxygen metabolite
dc.subjectterpenoid
dc.subjecttriterpenoid
dc.subjecttumor necrosis factor alpha
dc.subjectunclassified drug
dc.subjectantineoplastic activity
dc.subjectapoptosis
dc.subjectcell cycle arrest
dc.subjectcell proliferation
dc.subjectcolon cancer
dc.subjectcytokine production
dc.subjectcytotoxicity
dc.subjectdendritic cell
dc.subjectdrug isolation
dc.subjectGanoderma lucidum
dc.subjecthuman
dc.subjectimmunomodulation
dc.subjectinnate immunity
dc.subjectmacrophage
dc.subjectnatural killer cell
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectspleen lymphocyte
dc.subjectT lymphocyte
dc.subjectTh1 cell
dc.subjecttumor cell destruction
dc.subjectBasidiomycota
dc.titleAntitumor properties of Ganoderma lucidum polysaccharides and terpenoidsen
dc.typeArtigo
dcterms.licensehttp://arbs.biblioteca.unesp.br/index.php/arbs/about
unesp.author.lattes8845835550637809[2]
unesp.author.orcid0000-0002-4292-3298[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Microbiologia e Imunologia - IBB
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