Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine, in dogs

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dc.contributor.authorMonteiro, Eduardo Raposo
dc.contributor.authorRodrigues, Adolfo
dc.contributor.authorAssis, Hemir Martins Quirilos
dc.contributor.authorCampagnol, Daniela [UNESP]
dc.contributor.authorQuitzan, Juliany Gomes [UNESP]
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:39:13Z
dc.date.available2014-05-20T13:39:13Z
dc.date.issued2009-01-01
dc.description.abstractTo compare the effects of morphine (MOR), methadone (MET), butorphanol (BUT) and tramadol (TRA), in combination with acepromazine, on sedation, cardiorespiratory variables, body temperature and incidence of emesis in dogs.Prospective randomized, blinded, experimental trial.Six adult mixed-breed male dogs weighing 12.0 +/- 4.3 kg.Dogs received intravenous administration (IV) of acepromazine (0.05 mg kg(-1)) and 15 minutes later, one of four opioids was randomly administered IV in a cross-over design, with at least 1-week intervals. Dogs then received MOR 0.5 mg kg(-1); MET 0.5 mg kg(-1); BUT 0.15 mg kg(-1); or TRA 2.0 mg kg(-1). Indirect systolic arterial pressure (SAP), heart rate (HR), respiratory rate (f(R)), rectal temperature, pedal withdrawal reflex and sedation were evaluated at regular intervals for 90 minutes.Acepromazine administration decreased SAP, HR and temperature and produced mild sedation. All opioids further decreased temperature and MOR, BUT and TRA were associated with further decreases in HR. Tramadol decreased SAP whereas BUT decreased f(R) compared with values before opioid administration. Retching was observed in five of six dogs and vomiting occurred in one dog in MOR, but not in any dog in the remaining treatments. Sedation scores were greater in MET followed by MOR and BUT. Tramadol was associated with minor changes in sedation produced by acepromazine alone.When used with acepromazine, MET appears to provide better sedation than MOR, BUT and TRA. If vomiting is to be avoided, MET, BUT and TRA may be better options than MOR.en
dc.description.affiliationCtr Universidade Estadual de Maringá (UEM) CESUMAR, Fac Vet Med, Maringa, Parana, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Vet Surg & Anesthesiol, Fac Med Vet & Zootecn, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Vet Surg & Anesthesiol, Fac Med Vet & Zootecn, Botucatu, SP, Brazil
dc.description.sponsorshipPROBIC-CESUMAR (Programa de Bolsas de Iniciac, ciacao Cientifica - Centro Universitario de Maringa)
dc.format.extent25-33
dc.identifierhttp://dx.doi.org/10.1111/j.1467-2995.2008.00424.x
dc.identifier.citationVeterinary Anaesthesia and Analgesia. Malden: Wiley-blackwell Publishing, Inc, v. 36, n. 1, p. 25-33, 2009.
dc.identifier.doi10.1111/j.1467-2995.2008.00424.x
dc.identifier.issn1467-2987
dc.identifier.urihttp://hdl.handle.net/11449/13597
dc.identifier.wosWOS:000261685800004
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc
dc.relation.ispartofVeterinary Anaesthesia and Analgesia
dc.relation.ispartofjcr2.064
dc.relation.ispartofsjr0,800
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectacepromazineen
dc.subjectbutorphanolen
dc.subjectdogen
dc.subjectmethadoneen
dc.subjectmorphineen
dc.subjecttramadolen
dc.titleComparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine, in dogsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell Publishing, Inc
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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