The monosodium glutamate (MSG) obese rat as a model for the study of exercise in obesity

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dc.contributor.authorGobatto, C. A. [UNESP]
dc.contributor.authorMello, M. A R [UNESP]
dc.contributor.authorSouza, C. T. [UNESP]
dc.contributor.authorRibeiro, I. A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:20:35Z
dc.date.available2014-05-27T11:20:35Z
dc.date.issued2002-12-01
dc.description.abstractObesity is an increasing problem in several countries, leading to health problems. Physical exercise, in turn, can be used effectively by itself or in combination with dietary restriction to trigger weight loss. The present study was designed to evaluate the effects of aerobic exercise training on lipid profile of obese male Wistar rats in order to verify if this model may be of value for the study of exercise in obesity. Obesity was induced by MSG administration (4mg/g, each other day, from birth to 14 days old) After 14 from drug administration, the rats were separated into two groups: MSG-S (sedentary) and MSG-T (exercise trained). Exercise training consisted in 1h/day, 5 days/week, with an overload of 5% bw, for 10 weeks. Rats of the same age and strain, receiving saline at birth, were used as control (C), and subdivided into two groups: C-S and C-T. At the end of the experimental period, MSG-T and C-T rats showed similar blood lactate and muscle glycogen responses to exercise training and acute exercise. MSG-S rats showed significantly higher carcass fat, serum triacylglycerol, serum insulin and liver total fat than C-S rats. On the other hand, MSG-T rats had lower carcass fat, serum triacylglycerol and liver total fat than MSG-S rats. There were no statistical differences in food intake and serum free fatty acids among the groups studied. These data indicate that this model may be of value for the study of exercise effects on tissue and circulating lipid profile in obesity.en
dc.description.affiliationDepartamento de Educacao Fisica I.B. Univ. Estadual Paulista - UNESP, Avenida 24-A, 1515, Rio Claro - São Paulo
dc.description.affiliationUnespDepartamento de Educacao Fisica I.B. Univ. Estadual Paulista - UNESP, Avenida 24-A, 1515, Rio Claro - São Paulo
dc.format.extent89-101
dc.identifier.citationResearch Communications in Molecular Pathology and Pharmacology, v. 111, n. 1-4, p. 89-101, 2002.
dc.identifier.issn1078-0297
dc.identifier.scopus2-s2.0-0141732101
dc.identifier.urihttp://hdl.handle.net/11449/67144
dc.language.isoeng
dc.relation.ispartofResearch Communications in Molecular Pathology and Pharmacology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBlood lactate
dc.subjectBody weight
dc.subjectCarcass fat
dc.subjectExercise
dc.subjectLipid profile
dc.subjectMonosodium glutamate (MSG)
dc.subjectObesity
dc.subjectSerum triacylglycerol
dc.subjectfat
dc.subjectfatty acid
dc.subjectglucose
dc.subjectglutamate sodium
dc.subjectglycogen
dc.subjectinsulin
dc.subjectlactic acid
dc.subjecttriacylglycerol
dc.subjectaerobic metabolism
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectcontrolled study
dc.subjectdiet restriction
dc.subjectdisease model
dc.subjectevaluation
dc.subjectexercise
dc.subjectfemale
dc.subjectfood intake
dc.subjectlipid blood level
dc.subjectmale
dc.subjectmonosodium glutamate obese rat model
dc.subjectnonhuman
dc.subjectobesity
dc.subjectphysical activity
dc.subjectpriority journal
dc.subjectrat
dc.subjectstatistical significance
dc.subjecttraining
dc.subjectweight reduction
dc.subjectAnimals
dc.subjectDisease Models, Animal
dc.subjectFemale
dc.subjectMale
dc.subjectPhysical Conditioning, Animal
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSodium Glutamate
dc.titleThe monosodium glutamate (MSG) obese rat as a model for the study of exercise in obesityen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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