Synthesis and antimycobacterial activity of new pyrazolate-bridged dinuclear complexes of the type [Pd(mu-L)(N-3)(PPh3)](2) (PPh3 = triphenylphosphine; L = pyrazolates)

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dc.contributor.authorSilva, C. da [UNESP]
dc.contributor.authorFerreira, J. G. [UNESP]
dc.contributor.authorMauro, A. E. [UNESP]
dc.contributor.authorFrem, R. C. G. [UNESP]
dc.contributor.authorSantos, R. H. A.
dc.contributor.authorSilva, P. B. da [UNESP]
dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorMarino, L. B. [UNESP]
dc.contributor.authorLeite, Clarice Queico Fujimura [UNESP]
dc.contributor.authorNetto, A. V. G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-03-18T15:53:33Z
dc.date.available2015-03-18T15:53:33Z
dc.date.issued2014-10-01
dc.description.abstractBinuclear compounds of the type [Pd(mu-L)(N-3)(PPh3)](2) {L = pyrazolate (1); 3,5-dimethylpyrazolate (2); 4-iodopyrazolate (3); PPh3 = triphenylphosphine} were synthesized and characterized by elemental analyses, infrared and H-1 and P-31{H-1} NMR spectroscopies. The crystal and molecular structures of the complex [Pd(mu-dmPz)(N-3)(PPh3)](2) (2) were determined by single-crystal X-ray diffraction techniques. In vitro antimycobacterial evaluation demonstrated that compound [Pd(mu-Pz)(N-3)(PPh3)](2) (1) displayed a MIC of 8.16 mu M, being more active than some commonly used anti-TB drugs and other Pd(II) complexes. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Inst Quim Araraquara, Araraquara, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim Araraquara, Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 12/15486-3
dc.description.sponsorshipIdCNPq: 475322/2009-6
dc.description.sponsorshipIdCNPq: 487092/2012-0
dc.format.extent153-155
dc.identifierhttp://dx.doi.org/10.1016/j.inoche.2014.09.001
dc.identifier.citationInorganic Chemistry Communications. Amsterdam: Elsevier Science Bv, v. 48, p. 153-155, 2014.
dc.identifier.doi10.1016/j.inoche.2014.09.001
dc.identifier.issn1387-7003
dc.identifier.lattes2114570774349859
dc.identifier.lattes7927677053650819
dc.identifier.lattes8534138813417161
dc.identifier.orcid0000-0002-0057-7964
dc.identifier.orcid0000-0003-1574-681X
dc.identifier.urihttp://hdl.handle.net/11449/116580
dc.identifier.wosWOS:000343362500036
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInorganic Chemistry Communications
dc.relation.ispartofjcr1.810
dc.relation.ispartofsjr0,430
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBinuclear Pd(II) compoundsen
dc.subjectTriphenylphosphineen
dc.subjectPyrazolatesen
dc.subjectMycobacterium tuberculosisen
dc.titleSynthesis and antimycobacterial activity of new pyrazolate-bridged dinuclear complexes of the type [Pd(mu-L)(N-3)(PPh3)](2) (PPh3 = triphenylphosphine; L = pyrazolates)en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2114570774349859
unesp.author.lattes7927677053650819[10]
unesp.author.lattes3300223970814448[3]
unesp.author.lattes8534138813417161[4]
unesp.author.orcid0000-0002-0057-7964[10]
unesp.author.orcid0000-0002-6969-3963[7]
unesp.author.orcid0000-0003-0047-4671[3]
unesp.author.orcid0000-0003-1574-681X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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