Mycetoma caused by Nocardia brasiliensis in an immunocompetent patient

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dc.contributor.authorSousa, Juliana M. P.
dc.contributor.authorWachholz, Patrick Alexander [UNESP]
dc.contributor.authorSette, Christiane S.
dc.contributor.authorMarques, Gabriela F.
dc.contributor.authorBarreto, Jaison A.
dc.contributor.institutionLauro de Souza Lima Inst
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:55:11Z
dc.date.available2015-03-18T15:55:11Z
dc.date.issued2014-10-01
dc.description.abstractDendritic cells play a central role in the regulation of immunological reactivity. The existence of functionally specialized populations of dendritic cells in the skin is a consequence of qualitatively different attacks on our organism. slanDCs are human inflammatory dendritic cells that are characterized by the specific expression of the carbohydrate 6-sulfo LacNAc (slan). After phenotypic maturation, slanDCs are capable of producing very high amounts of proinflammatory mediators such as IL-12, TNF-, IL-1 and IL-23. Recent data describe a potential role of slanDCs in a number of different diseases like psoriasis, lupus erythematosus, and tumors, thus opening up new areas of research on their respective pathogenesis. Furthermore, a slanDC-specific targeting system has been developed as a basis for direct therapeutic manipulation. Future challenges of slanDC research include deepening our understanding of the significance of slanDCs in the regulation of adaptive and innate immune responses, as well as translating this knowledge into therapeutic options.en
dc.description.affiliationLauro de Souza Lima Inst, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista Julio de Mesquita Filho FM, Botucatu Med Sch, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio de Mesquita Filho FM, Botucatu Med Sch, Sao Paulo, Brazil
dc.format.extent903-905
dc.identifierhttp://dx.doi.org/10.1111/ddg.12331
dc.identifier.citationJournal Der Deutschen Dermatologischen Gesellschaft. Hoboken: Wiley-blackwell, v. 12, n. 10, p. 903-905, 2014.
dc.identifier.doi10.1111/ddg.12331
dc.identifier.issn1610-0379
dc.identifier.urihttp://hdl.handle.net/11449/117103
dc.identifier.wosWOS:000342750400007
dc.language.isodeu
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Der Deutschen Dermatologischen Gesellschaft
dc.relation.ispartofjcr2.743
dc.relation.ispartofsjr0,704
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleMycetoma caused by Nocardia brasiliensis in an immunocompetent patienten
dc.typeCarta
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.orcid0000-0002-4474-009X[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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