Antimicrobial effects of terpinen-4-ol against oral pathogens and its capacity for the modulation of gene expression

Página do item simplificado
dc.contributor.authorBordini, Ester Alves Ferreira [UNESP]
dc.contributor.authorTonon, Caroline Coradi [UNESP]
dc.contributor.authorFrancisconi, Renata Serignoli [UNESP]
dc.contributor.authorMagalhães, Fernando Augusto Cintra [UNESP]
dc.contributor.authorHuacho, Patrícia Milagros Maquera [UNESP]
dc.contributor.authorBedran, Telma Lombardo
dc.contributor.authorPratavieira, Sebastião
dc.contributor.authorSpolidorio, Luis Carlos [UNESP]
dc.contributor.authorSpolidorio, Denise Palomari [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Nove de Julho
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2019-10-06T16:53:08Z
dc.date.available2019-10-06T16:53:08Z
dc.date.issued2018-08-09
dc.description.abstractThis study evaluated the antibacterial activity of terpinen-4-ol against Streptococcus mutans and Lactobacillus acidophilus and its influence on gbpA (S. mutans) and slpA (L. acidophilus) gene expression. As measured by XTT assay, the concentrations of terpinen-4-ol that effectively inhibited the biofilm were 0.24% and 0.95% for S. mutans and L. acidophilus, respectively. Confocal microscopy revealed the presence of a biofilm attached to the enamel and dentin block surfaces with significant terpinen-4-ol effects against these microorganisms. The expression of the gbpA and slpA genes involved in adherence and biofilm formation was investigated using RT-PCR. Expression of these genes decreased after 15 min with 0.24% and 0.95% terpinen-4-ol in S. mutans and L. acidophilus, respectively. These findings demonstrate the antimicrobial activity of terpinen-4-ol and its ability to modulate the expression of gbpA and slpA genes, emphasizing the therapeutic capacity of terpinen-4-ol as an alternative to inhibit adherence in biofilm.en
dc.description.affiliationDepartment of Physiology and Pathology State University of Sao Paulo/UNESP
dc.description.affiliationDepartment of Periodontology Universidade Nove de Julho
dc.description.affiliationPhysics Institute of São Carlos University of São Paulo USP
dc.description.affiliationUnespDepartment of Physiology and Pathology State University of Sao Paulo/UNESP
dc.format.extent815-825
dc.identifierhttp://dx.doi.org/10.1080/08927014.2018.1504926
dc.identifier.citationBiofouling, v. 34, n. 7, p. 815-825, 2018.
dc.identifier.doi10.1080/08927014.2018.1504926
dc.identifier.issn1029-2454
dc.identifier.issn0892-7014
dc.identifier.lattes2640929291808415
dc.identifier.scopus2-s2.0-85055084883
dc.identifier.urihttp://hdl.handle.net/11449/189817
dc.language.isoeng
dc.relation.ispartofBiofouling
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectbiofilms
dc.subjectMicroorganisms
dc.subjectterpinen-4-ol
dc.titleAntimicrobial effects of terpinen-4-ol against oral pathogens and its capacity for the modulation of gene expressionen
dc.typeArtigo
unesp.author.lattes2640929291808415

Arquivos

Coleções

Artigos - Fisiologia e Patologia - FOAR