Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats

Página do item simplificado
dc.contributor.authorMelo Luvizotto, Renata de Azevedo [UNESP]
dc.contributor.authorNascimento, Andre F. [UNESP]
dc.contributor.authorImaizumi, Erika [UNESP]
dc.contributor.authorPierine, Damiana T. [UNESP]
dc.contributor.authorConde, Sandro J. [UNESP]
dc.contributor.authorCorrêa, Camila Renata [UNESP]
dc.contributor.authorYeum, Kyung-Jin
dc.contributor.authorFerreira, Ana Lúcia dos Anjos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionTufts Univ
dc.contributor.institutionKonkuk Univ
dc.date.accessioned2014-12-03T13:10:30Z
dc.date.available2014-12-03T13:10:30Z
dc.date.issued2013-11-28
dc.description.abstractObesity is characterised by chronic low-grade inflammation, and lycopene has been reported to display anti-inflammatory effects. However, it is not clear whether lycopene supplementation modulates adipokine levels in vivo in obesity. To determine whether lycopene supplementation can regulate adipokine expression in obesity, male Wistar rats were randomly assigned to receive a control diet (C, n 6) or a hyperenergetic diet (DIO, n 12) for 6 weeks. After this period, the DIO animals were randomised into two groups: DIO (n 6) and DIO supplemented with lycopene (DIO + L, n 6). The animals received maize oil (C and DIO) or lycopene (DIO + L, 10 mg/kg body weight (BW) per d) by oral administration for a 6-week period. The animals were then killed by decapitation, and blood samples and epididymal adipose tissue were collected for hormonal determination and gene expression evaluation (IL-6, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, leptin and resistin). There was no detectable lycopene in the plasma of the C and DIO groups. However, the mean lycopene plasma concentration was 24 nmol in the DIO + L group. Although lycopene supplementation did not affect BW or adiposity, it significantly decreased leptin, resistin and IL-6 gene expression in epididymal adipose tissue and plasma concentrations. Also, it significantly reduced the gene expression of MCP-1 in epididymal adipose tissue. Lycopene affects adipokines by reducing leptin, resistin and plasma IL-6 levels. These data suggest that lycopene may be an effective strategy in reducing inflammation in obesity.en
dc.description.affiliationSao Paulo State Univ, UNESP, Botucatu Med Sch, Internal Med Lab,Dept Internal Med, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationTufts Univ, Human Nutr Res Ctr Aging, Jean Mayer United States Dept Agr, Boston, MA 02111 USA
dc.description.affiliationSao Paulo State Univ, UNESP, Botucatu Med Sch, Dept Pathol, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationKonkuk Univ, Coll Biomed & Hlth Sci, Seoul, South Korea
dc.description.affiliationUnespSao Paulo State Univ, UNESP, Botucatu Med Sch, Internal Med Lab,Dept Internal Med, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, UNESP, Botucatu Med Sch, Dept Pathol, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 10/06100-9
dc.description.sponsorshipIdFAPESP: 10/19746-4
dc.description.sponsorshipIdFAPESP: 11/19847-8
dc.description.sponsorshipIdFAPESP: 11/22786-0
dc.format.extent1803-1809
dc.identifierhttp://dx.doi.org/10.1017/S0007114513001256
dc.identifier.citationBritish Journal Of Nutrition. Cambridge: Cambridge Univ Press, v. 110, n. 10, p. 1803-1809, 2013.
dc.identifier.doi10.1017/S0007114513001256
dc.identifier.issn0007-1145
dc.identifier.lattes2940051650846541
dc.identifier.urihttp://hdl.handle.net/11449/112196
dc.identifier.wosWOS:000326883600007
dc.language.isoeng
dc.publisherCambridge University Press
dc.relation.ispartofBritish Journal of Nutrition
dc.relation.ispartofjcr3.657
dc.relation.ispartofsjr1,612
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectLycopeneen
dc.subjectObesityen
dc.subjectAdipokinesen
dc.titleLycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese ratsen
dc.typeArtigo
dcterms.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dcterms.rightsHolderCambridge Univ Press
unesp.author.lattes2940051650846541[8]
unesp.author.orcid0000-0003-1876-5418[5]
unesp.author.orcid0000-0002-5267-1127[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Coleções

Artigos - Clínica Médica - FMB
Artigos - Patologia - FMB