Supraphysiological Triiodothyronine Doses Diminish Leptin and Adiponectin Gene Expression, but do not Alter Resistin Expression in Calorie Restricted Obese Rats

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dc.contributor.authorLuvizotto, R. A. M. [UNESP]
dc.contributor.authorSibio, M. T. [UNESP]
dc.contributor.authorOlimpio, R. M. C. [UNESP]
dc.contributor.authorNascimento, A. F. [UNESP]
dc.contributor.authorLima-Leopoldo, A. P.
dc.contributor.authorLeopoldo, A. S. [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorCicogna, Antonio Carlos [UNESP]
dc.contributor.authorNogueira, Célia Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.date.accessioned2014-05-20T13:33:19Z
dc.date.available2014-05-20T13:33:19Z
dc.date.issued2011-06-01
dc.description.abstractThyroid hormones regulate energy balance and act on adipokines. However, while it is unclear what the effects are of calorie restriction and high doses of triiodothyronine (T(3)) on adipokines in obesity, thyroid hormones are illicitly administered in isolation or in association with a hypocaloric diet as an obesity treatment. The present study determined the effect of T(3) on serum concentrations and gene expression of the adipokines leptin, resistin, and adiponectin in calorie-restricted obese rats. Male Wistar rats received a hypercaloric diet for 20 weeks followed by calorie restriction for 8 weeks. The animals were then randomly divided into 3 groups: calorie restriction (OR), OR with 5 mu g of T(3)/100g BW (RS1), and OR with 25 mu g of T(3)/100g BW (RS2) for 2 weeks. Blood and adipose tissue samples were collected for biochemical, hormonal, and gene expression analyses. Serum concentrations of leptin (OR: 3.7 +/- 0.6, RS1: 3.8 +/- 1, RS2 0.2 +/- 0.07 ng/dl) and resistin (OR: 2.5 +/- 0.6, RS1: 2.5 +/- 0.5, RS2 1.6 +/- 0.3 ng/dl) were diminished at the higher dose, while serum adiponectin (OR: 31 +/- 7, RS1: 24 +/- 5, RS2 26 +/- 7 ng/dl) levels were lower in the low dose group. Administration of T(3) reduced leptin gene expression (OR: 0.91 +/- 0.1, RS1: 0.95 +/- 0.1, RS2 0.22 +/- 0.1) only at the higher dose, resistin expression (OR: 1.06 +/- 0.2, RS1: 1.04 +/- 0.1, RS2 0.88 +/- 0.2) was not influenced by T(3) treatment, and adiponectin expression (OR: 1.55 +/- 0.5, RS1: 0.95 +/- 0.15, RS2 0.97 +/- 0.13) was diminished independent of the T(3) dose. These results indicate that T(3), directly or indirectly, inhibits the expression of leptin and adiponectin in calorie restricted obese animals.en
dc.description.affiliationUniv São Paulo State UNESP, Botucatu Sch Med, Dept Clin Med, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUFES Fed Univ Espirito Santo, Dept Sports, Ctr Phys Educ & Sports, Vitoria, Esprito Santo, Brazil
dc.description.affiliationUniv São Paulo State UNESP, Inst Biol Sci, Dept Biostat, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv São Paulo State UNESP, Botucatu Sch Med, Dept Clin Med, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv São Paulo State UNESP, Inst Biol Sci, Dept Biostat, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 06/58177-0
dc.description.sponsorshipIdFAPESP: 07/50041-4
dc.format.extent452-457
dc.identifierhttp://dx.doi.org/10.1055/s-0031-1277187
dc.identifier.citationHormone and Metabolic Research. Stuttgart: Georg Thieme Verlag Kg, v. 43, n. 7, p. 452-457, 2011.
dc.identifier.doi10.1055/s-0031-1277187
dc.identifier.issn0018-5043
dc.identifier.lattes9418970103564137
dc.identifier.lattes8727897080522289
dc.identifier.urihttp://hdl.handle.net/11449/11395
dc.identifier.wosWOS:000292825900002
dc.language.isoeng
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofHormone and Metabolic Research
dc.relation.ispartofjcr2.560
dc.relation.ispartofsjr0,918
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectthyroid hormoneen
dc.subjectadipose tissueen
dc.subjecthigh-fat dieten
dc.subjectfood deprivationen
dc.titleSupraphysiological Triiodothyronine Doses Diminish Leptin and Adiponectin Gene Expression, but do not Alter Resistin Expression in Calorie Restricted Obese Ratsen
dc.typeArtigo
dcterms.licensehttps://www.thieme.de/cps/rde/xbcr/classic/thieme_ir_policy_english.pdf
dcterms.rightsHolderGeorg Thieme Verlag Kg
unesp.author.lattes9418970103564137[8]
unesp.author.lattes8727897080522289[7]
unesp.author.lattes7607038776901890[9]
unesp.author.orcid0000-0002-7354-9518[9]
unesp.author.orcid0000-0002-7719-9682[7]
unesp.author.orcid0000-0002-4402-6523[8]
unesp.author.orcid0000-0002-4014-0660[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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