Expression of cell cycle proteins according to HPV status in oral squamous cell carcinoma affecting young patients: a pilot study

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dc.contributor.authorGalvis, Marisol Miranda
dc.contributor.authorJardim, Juscelino Freitas
dc.contributor.authorKaminagakura, Estela [UNESP]
dc.contributor.authorSantos-Silva, Alan Roger
dc.contributor.authorFonseca, Felipe Paiva
dc.contributor.authorAlmeida, Oslei Paes
dc.contributor.authorLopes, Marcio Ajudarte
dc.contributor.authorPinto, Clovis Lopes
dc.contributor.authorKowalski, Luiz Paulo
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionAC Camargo Canc Ctr
dc.date.accessioned2018-11-26T17:49:07Z
dc.date.available2018-11-26T17:49:07Z
dc.date.issued2018-04-01
dc.description.abstractObjective. Tobacco and alcohol consumption are considered the main risk factors for oral squamous cell carcinoma (OSCC); however, the role of these factors in patients younger than 40 years is controversial, so it has been suggested that genomic instability and high-risk human papillomavirus (HR-HPV) infection may be contributing factors to oral carcinogenesis at a young age. Therefore, the aim of this study was to evaluate the immunoexpression of cell cycle proteins according HPV status in OSCC affecting young patients. Methods. A tissue microarray construction based on 34 OSCC samples from young patients (<40 years old) was subjected to immunohistochemical reactions for Ki67, cyclin D1, C-ErbB2, p21, Myc, epidermal growth factor receptor, p53, and p16 antibodies. Results. The clinicopathologic features and the immunoexpression of all tested proteins were similar in both groups. Patients with HPV-related OSSC tended to have better cancer-specific survival (CSS; 39% vs 60% 5-y CSS), and overall survival (OS; 29.2% vs 60% 5-year OS). However, this difference was not statistically significant. Conclusion. No significant difference exists in the expression of cell cycle proteins studied between HR-HPV DNA-positive and HR-HPV DNA-negative OSCC affecting young patients.en
dc.description.affiliationUniv Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, Brazil
dc.description.affiliationUniv Estadual Paulista, Sci & Technol Inst, Dept Biosci & Oral Diag, Sao Jose Dos Campos, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, Belo Horizonte, MG, Brazil
dc.description.affiliationAC Camargo Canc Ctr, Dept Anat Pathol, Sao Paulo, Brazil
dc.description.affiliationAC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Rua Prof Antonio Prudente 211, BR-01509900 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sci & Technol Inst, Dept Biosci & Oral Diag, Sao Jose Dos Campos, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent317-325
dc.identifierhttp://dx.doi.org/10.1016/j.oooo.2018.01.003
dc.identifier.citationOral Surgery Oral Medicine Oral Pathology Oral Radiology. New York: Elsevier Science Inc, v. 125, n. 4, p. 317-325, 2018.
dc.identifier.doi10.1016/j.oooo.2018.01.003
dc.identifier.fileWOS000429971300013.pdf
dc.identifier.issn2212-4403
dc.identifier.urihttp://hdl.handle.net/11449/164103
dc.identifier.wosWOS:000429971300013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofOral Surgery Oral Medicine Oral Pathology Oral Radiology
dc.relation.ispartofsjr0,720
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleExpression of cell cycle proteins according to HPV status in oral squamous cell carcinoma affecting young patients: a pilot studyen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0003-2040-6617[4]

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