Effects of a muscarinic type-2 antagonist on cardiorespiratory function and intestinal transit in horses anesthetized with halothane and xylazine

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dc.contributor.authorTeixeira Neto, Francisco José [UNESP]
dc.contributor.authorMcDonell, W. N.
dc.contributor.authorBlack, W. D.
dc.contributor.authorMoraes, A. N.
dc.contributor.authorDuronghphongtorn, S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Guelph
dc.date.accessioned2014-05-20T13:31:51Z
dc.date.available2014-05-20T13:31:51Z
dc.date.issued2004-04-01
dc.description.abstractObjective-To evaluate the cardiorespiratory and intestinal effects of the muscarinic type-2 (M-2) antagonist, methoctramine, in anesthetized horses.Animals-6 horses.Procedure-Horses were allocated to 2 treatments in a randomized complete block design. Anesthesia was maintained with halothane (1% end-tidal concentration) combined with a constant-rate infusion of xylazine hydrochloride (1 mg/kg/h, IV) and mechanical ventilation. Hemodynamic variables were monitored after induction of anesthesia and for 120 minutes after administration of methoctramine or saline (0.9% NaCl) solution (control treatment). Methoctramine was given at 10-minute intervals (10 mug/kg, IV) until heart rate (HR) increased at least 30% above baseline values or until a maximum cumulative dose of 30 mug/kg had been administered. Recovery characteristics, intestinal auscultation scores, and intestinal transit determined by use of chromium oxide were assessed during the postanesthetic period.Results-Methoctramine was given at a total cumulative dose of 30 mug/kg to 4 horses, whereas 2 horses received 10 mug/kg. Administration of methoctramine resulted in increases in HR, cardiac output, arterial blood pressure, and tissue oxygen delivery. Intestinal auscultation scores and intestinal transit time (interval to first and last detection of chromium oxide in the feces) did not differ between treatment groups.Conclusions and Clinical Relevance-Methoctramine improved hemodynamic function in horses anesthetized by use of halothane and xylazine without causing a clinically detectable delay in the return to normal intestinal motility during the postanesthetic period. Because of their selective positive chronotropic effects, M-2 antagonists may represent a safe alternative for treatment of horses with intraoperative bracycardia.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med Vet & Zootecnia, Dept Vet Surg & Anesthesiol, BR-14870000 Botucatu, SP, Brazil
dc.description.affiliationUniv Guelph, Ontario Vet Coll, Dept Biomed Sci, Guelph, ON N1G 2W1, Canada
dc.description.affiliationUniv Guelph, Ontario Vet Coll, Dept Clin Studies, Guelph, ON N1G 2W1, Canada
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Med Vet & Zootecnia, Dept Vet Surg & Anesthesiol, BR-14870000 Botucatu, SP, Brazil
dc.format.extent464-472
dc.identifierhttp://dx.doi.org/10.2460/ajvr.2004.65.464
dc.identifier.citationAmerican Journal of Veterinary Research. Schaumburg: Amer Veterinary Medical Assoc, v. 65, n. 4, p. 464-472, 2004.
dc.identifier.doi10.2460/ajvr.2004.65.464
dc.identifier.issn0002-9645
dc.identifier.urihttp://hdl.handle.net/11449/10842
dc.identifier.wosWOS:000220367200014
dc.language.isoeng
dc.publisherAmer Veterinary Medical Assoc
dc.relation.ispartofAmerican Journal of Veterinary Research
dc.relation.ispartofjcr0.833
dc.relation.ispartofsjr0,567
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleEffects of a muscarinic type-2 antagonist on cardiorespiratory function and intestinal transit in horses anesthetized with halothane and xylazineen
dc.typeArtigo
dcterms.licensehttps://www.avma.org/News/Journals/Pages/journals-reprints.aspx
dcterms.rightsHolderAmer Veterinary Medical Assoc
unesp.author.orcid0000-0002-3002-8093[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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Artigos - Cirurgia e Anestesiologia Veterinária - FMVZ