Evaluation of the genotoxic potential of the isocoumarin paepalantine in in vivo and in vitro mammalian systems

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dc.contributor.authorTavares, D. C.
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.authorAndrade, FDP
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorTakahashi, C. S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:24:57Z
dc.date.available2014-05-20T13:24:57Z
dc.date.issued1999-12-15
dc.description.abstractPaepalantine is an isocoumarin isolated from Paepalanthus vellozioides which showed antimicrobial activity in in vitro experiments. In the present study, paepalantine was tested for possible clastogenic and cytotoxic action. Cultures from different individuals were treated with paepalantine at concentrations of 20, 40 and 80 mu g/ml. The effect of isocoumarin was also tested in an in vivo assay using Wistar rat bone marrow cells. Paepalantine was administered intraperitoneally at concentrations of 6.25, 12.5 and 25 mg/kg body weight. Under these conditions paepalantine did not have a clastogenic effect, but was significantly cytotoxic in the in vitro and in vivo mammalian cell systems tested in the present work. (C) 1999 Elsevier B.V. Ireland Ltd. All rights reserved.en
dc.description.affiliationUNESP, Fac Ciências Farmaceut Araraquara, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Inst Quim Araraquara, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUSP, Dept Biol, Fac Filosofia Ciências & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, Brazil
dc.description.affiliationUnespUNESP, Fac Ciências Farmaceut Araraquara, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Quim Araraquara, BR-14800900 Araraquara, SP, Brazil
dc.format.extent115-120
dc.identifierhttp://dx.doi.org/10.1016/S0378-8741(99)00061-6
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 68, n. 1-3, p. 115-120, 1999.
dc.identifier.doi10.1016/S0378-8741(99)00061-6
dc.identifier.issn0378-8741
dc.identifier.lattes7501930236496670
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/7874
dc.identifier.wosWOS:000083704900013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectpaepalantinept
dc.subjectisocoumarinpt
dc.subjectchromosomal aberrationspt
dc.subjectcytotoxicitypt
dc.titleEvaluation of the genotoxic potential of the isocoumarin paepalantine in in vivo and in vitro mammalian systemsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes7501930236496670
unesp.author.orcid0000-0003-3367-539X[5]
unesp.author.orcid0000-0003-3032-2556[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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