Morphological alterations on the prostate of Calomys callosus submitted to chronic ethanol ingestion

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dc.contributor.authorMartinez, M.
dc.contributor.authorMello, W. [UNESP]
dc.contributor.authorPadovani, C. R. [UNESP]
dc.contributor.authorMartinez, F. E. [UNESP]
dc.contributor.authorMilton, F. A.
dc.contributor.authorDe Oliveira, S. A.
dc.contributor.authorReis, G. S.
dc.contributor.authorPereira, S. [UNESP]
dc.contributor.authorSegatelli, T. M. [UNESP]
dc.contributor.authorPinheiro, P. F F [UNESP]
dc.contributor.authorAlmeida, C. C D [UNESP]
dc.contributor.authorCagnon, V. H A
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-27T11:21:55Z
dc.date.available2014-05-27T11:21:55Z
dc.date.issued2006-07-01
dc.description.abstractThe objective of the present study was to assess the possible toxic effects of chronic alcohol ingestion on the ultrastructure of the glandular epithelium of the prostate of the rodent Calomys callosus, in order to contribute to the understanding of the consequences of alcohol abuse for the morphology of the male reproductive apparatus. Sixteen adult animals aged three months were divided into two experimental groups. The control group received a solid diet and tap water, and the alcoholic group received the same solid diet and ethanol P.A. diluted 20% in water (v/v). After 120 days of treatment, all animals were anesthetized, weighed and sacrificed. At the end of treatment, mean body weight did not differ between control and alcoholic animals. The prostate epithelial cells of the alcoholic group showed intense atrophy and ultrastructural alterations such as the presence of lipid droplets, altered nuclei, ruptured mitochondrial cristae, and intense dilatation of the cisterns of the granular endoplasmic reticulum. It was concluded that 20% ethanol provokes marked lesions on the epithelium of the prostate probably interfering on the glandular secretion.en
dc.description.affiliationDepartment of Morphology and Pathology UFSCar, São Carlos, SP
dc.description.affiliationDepartment of Anatomy UNESP, Botucatu, SP
dc.description.affiliationDepartment of Anatomy University of Campinas, SP
dc.description.affiliationDepartment of Biostatistics UNESP, Botucatu, SP
dc.description.affiliationDepartamento de Morfologia e Patologia Universidade Federal de São Carlos, Rod. Washington Luis Km 235 s/no, CEP: 13.565.905São Carlos, SP
dc.description.affiliationUnespDepartment of Anatomy UNESP, Botucatu, SP
dc.description.affiliationUnespDepartment of Biostatistics UNESP, Botucatu, SP
dc.format.extent117-123
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17784639
dc.identifier.citationJournal of Submicroscopic Cytology and Pathology, v. 38, n. 2-3, p. 117-123, 2006.
dc.identifier.issn1122-9497
dc.identifier.lattes8727897080522289
dc.identifier.lattes1739564105219382
dc.identifier.orcid0000-0003-0030-8198
dc.identifier.scopus2-s2.0-34548086522
dc.identifier.urihttp://hdl.handle.net/11449/68979
dc.language.isoeng
dc.relation.ispartofJournal of Submicroscopic Cytology and Pathology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAlcohol
dc.subjectAlcoholism
dc.subjectCalomys callosus
dc.subjectEpithelium
dc.subjectProstate
dc.subjectalcohol
dc.subjectalcoholism
dc.subjectanimal
dc.subjectatrophy
dc.subjectbody weight
dc.subjectchemically induced disorder
dc.subjectdisease model
dc.subjectdrug effect
dc.subjectepithelium cell
dc.subjectmale
dc.subjectpathology
dc.subjectprostate
dc.subjectrodent
dc.subjectscanning electron microscopy
dc.subjecttransmission electron microscopy
dc.subjectultrastructure
dc.subjectAnimals
dc.subjectAtrophy
dc.subjectBody Weight
dc.subjectDisease Models, Animal
dc.subjectEpithelial Cells
dc.subjectEthanol
dc.subjectMale
dc.subjectMicroscopy, Electron, Scanning
dc.subjectMicroscopy, Electron, Transmission
dc.subjectRodentia
dc.subjectAnimalia
dc.titleMorphological alterations on the prostate of Calomys callosus submitted to chronic ethanol ingestionen
dc.typeArtigo
unesp.author.lattes8727897080522289[3]
unesp.author.lattes1739564105219382
unesp.author.orcid0000-0003-0030-8198[8]
unesp.author.orcid0000-0002-7719-9682[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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