Candida Biofilms: An Update on Developmental Mechanisms and Therapeutic Challenges

Página do item simplificado
dc.contributor.authorde Barros, Patrícia Pimentel [UNESP]
dc.contributor.authorRossoni, Rodnei Dennis [UNESP]
dc.contributor.authorde Souza, Cheyenne Marçal [UNESP]
dc.contributor.authorScorzoni, Liliana [UNESP]
dc.contributor.authorFenley, Juliana De Camargo [UNESP]
dc.contributor.authorJunqueira, Juliana Campos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T02:02:01Z
dc.date.available2020-12-12T02:02:01Z
dc.date.issued2020-06-01
dc.description.abstractFungi of the genus Candida are important etiological agents of superficial and life-threatening infections in individuals with a compromised immune system. One of the main characteristics of Candida is its ability to form highly drug tolerance biofilms in the human host. Biofilms are a dynamic community of multiple cell types whose formation over time is orchestrated by a network of transcription regulators. In this brief review, we provide an update of the processes involved in biofilm formation by Candida spp. (formation, treatment, and control), as well as the transcriptional circuitry that regulates its development and interactions with other microorganisms. Candida albicans is known to build mixed species biofilms with other Candida species and with various other bacterial species in different host niches. Taken together, these properties play a key role in Candida pathogenesis. In addition, this review gathers recent studies with new insights and perspectives for the treatment and control of Candida biofilms.en
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis São Paulo State University (Unesp) Institute of Science and Technology São José dos Campos, Avenida Engenheiro Francisco José Longo 777, São Dimas
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis São Paulo State University (Unesp) Institute of Science and Technology São José dos Campos, Avenida Engenheiro Francisco José Longo 777, São Dimas
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2017/02652-6
dc.description.sponsorshipIdFAPESP: 2017/19219-3
dc.description.sponsorshipIdFAPESP: 2019/05664-0
dc.description.sponsorshipIdCNPq: 306330/2018-0
dc.format.extent415-424
dc.identifierhttp://dx.doi.org/10.1007/s11046-020-00445-w
dc.identifier.citationMycopathologia, v. 185, n. 3, p. 415-424, 2020.
dc.identifier.doi10.1007/s11046-020-00445-w
dc.identifier.issn1573-0832
dc.identifier.issn0301-486X
dc.identifier.scopus2-s2.0-85083116576
dc.identifier.urihttp://hdl.handle.net/11449/200267
dc.language.isoeng
dc.relation.ispartofMycopathologia
dc.sourceScopus
dc.subjectAlternative treatment
dc.subjectBiofilms
dc.subjectCandida spp
dc.subjectPolymicrobial biofilms
dc.subjectTranscriptional circuitry
dc.titleCandida Biofilms: An Update on Developmental Mechanisms and Therapeutic Challengesen
dc.typeResenha
unesp.author.orcid0000-0003-4885-2811[1]
unesp.author.orcid0000-0002-9977-3040[2]
unesp.author.orcid0000-0002-0178-6653[4]
unesp.author.orcid0000-0001-6646-6856[6]

Arquivos

Coleções

Artigos - Biociências e Diagnóstico Bucal - ICT