Proinflammatory cytokine production from NOK-SI keratinocytes after exposure to denture adhesives

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dc.contributor.authorPerin Leite, Andressa Rosa [UNESP]
dc.contributor.authorde Oliveira Júnior, Norberto Martins [UNESP]
dc.contributor.authorMendoza Marin, Danny Omar [UNESP]
dc.contributor.authorCompagnoni, Marco Antonio [UNESP]
dc.contributor.authorPero, Ana Carolina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:13:08Z
dc.date.available2018-12-11T17:13:08Z
dc.date.issued2018-03-01
dc.description.abstractStatement of problem: Although the cytotoxicity of denture adhesives has been widely assessed, data on the release of proinflammatory cytokines from oral epithelial cells are still scarce. Purpose: The purpose of this in vitro study was to evaluate the proinflammatory cytokines interleukin (IL) 1β IL-6, and tumor necrosis factor α (TNF-α) released from human oral keratinocytes after exposure to denture adhesives. Material and methods: Eluates of the Ultra Corega cream, Corega powder Fixador Ultra, and Corega strip denture adhesives were created at 1% wt/vol after 24 hours of exposure in a Dulbecco modified Eagle medium culture. The release of IL-1β IL-6, and TNF-α was measured using a sandwich enzyme-linked immunosorbent assay after the oral epithelial cells (NOK-SI) had been exposed to the eluates for 3, 6, and 24 hours (n=6). Results: IL-1β release from the strip was higher at 3 hours compared with the control (Bonferroni post hoc test, P=.016). IL-6 releases from the cream and powder denture adhesives at 6 and 24 hours were higher than for the controls (Bonferroni post hoc test, P<.05). TNF-α release was not detectable in some groups and periods. Conclusions: In long periods, denture adhesive strips do not induce any change on cytokine release from human oral keratinocytes.en
dc.description.affiliationDoctoral student Department of Dental Materials and Prosthodontics Araraquara Dental School São Paulo State University (UNESP)
dc.description.affiliationDepartment of Dental Materials and Prosthodontics Araraquara Dental School São Paulo State University (UNESP)
dc.description.affiliationUnespDoctoral student Department of Dental Materials and Prosthodontics Araraquara Dental School São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Dental Materials and Prosthodontics Araraquara Dental School São Paulo State University (UNESP)
dc.format.extent404-408
dc.identifierhttp://dx.doi.org/10.1016/j.prosdent.2017.04.009
dc.identifier.citationJournal of Prosthetic Dentistry, v. 119, n. 3, p. 404-408, 2018.
dc.identifier.doi10.1016/j.prosdent.2017.04.009
dc.identifier.file2-s2.0-85021853495.pdf
dc.identifier.issn0022-3913
dc.identifier.lattes8921196002764597
dc.identifier.scopus2-s2.0-85021853495
dc.identifier.urihttp://hdl.handle.net/11449/174846
dc.language.isoeng
dc.relation.ispartofJournal of Prosthetic Dentistry
dc.relation.ispartofsjr1,087
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleProinflammatory cytokine production from NOK-SI keratinocytes after exposure to denture adhesivesen
dc.typeArtigo
unesp.author.lattes2999722781960616[5]
unesp.author.lattes8921196002764597
unesp.author.orcid0000-0002-0203-2386[5]

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