A new experimental model of cigarette smoke-induced emphysema in Wistar rats

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dc.contributor.authorlas Heras Kozma, Rodrigo de
dc.contributor.authorAlves, Edson Marcelino [UNESP]
dc.contributor.authorBarbosa-de-Oliveira, Valter Abraao
dc.contributor.authorSantos, Lucinéia dos [UNESP]
dc.contributor.authorGuardia, Renan Cenize
dc.contributor.authorBuzo, Henrique Vivi
dc.contributor.authorFaria, Carolina Arruda de
dc.contributor.authorYamashita, Camila [UNESP]
dc.contributor.authorCavazzana Junior, Manzelio
dc.contributor.authorFrei, Fernando [UNESP]
dc.contributor.authorOliveira Ribeiro-Paes, Maria Jose de
dc.contributor.authorRibeiro-Paes, Joao Tadeu [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFac Integradas Padre Albino
dc.date.accessioned2014-12-03T13:09:11Z
dc.date.available2014-12-03T13:09:11Z
dc.date.issued2014-01-01
dc.description.abstractObjective: To describe a new murine model of cigarette smoke-induced emphysema. Methods: Twenty-four male Wistar rats were divided into two groups: the cigarette smoke group, comprising 12 rats exposed to smoke from 12 commercial filter cigarettes three times a day (a total of 36 cigarettes per day) every day for 30 weeks; and the control group, comprising 12 rats exposed to room air three times a day every day for 30 weeks. Lung function was assessed by mechanical ventilation, and emphysema was morphometrically assessed by measurement of the mean linear intercept (Lm). Results: The mean weight gain was significantly (approximately ten times) lower in the cigarette smoke group than in the control group. The Lm was 25.0% higher in the cigarette smoke group. There was a trend toward worsening of lung function parameters in the cigarette smoke group. Conclusions: The new murine model of cigarette smoke-induced emphysema and the methodology employed in the present study are effective and reproducible, representing a promising and economically viable option for use in studies investigating the pathophysiology of and therapeutic approaches to COPD.en
dc.description.affiliationUniv Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationJulio Mesquita Filho Sao Paulo State Univ, Assis Sch Sci & Languages, Assis, Brazil
dc.description.affiliationJulio Mesquita Filho Sao Paulo State Univ, Botucatu, SP, Brazil
dc.description.affiliationFac Integradas Padre Albino, Catanduva, Brazil
dc.description.affiliationUnespJulio Mesquita Filho Sao Paulo State Univ, Assis Sch Sci & Languages, Assis, Brazil
dc.description.affiliationUnespJulio Mesquita Filho Sao Paulo State Univ, Botucatu, SP, Brazil
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipAssis City Hall
dc.description.sponsorshipConsorcio Intermunicipal do Vale do Paranapanema/Saude (CIVAP/Saude, Paranapanema Valley Intermunicipal Consortium/Health)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFaculdades Integradas Padre Albino (FIPA, Padre Albino Integrated Colleges)
dc.format.extent46-54
dc.identifierhttp://dx.doi.org/10.1590/S1806-37132014000100007
dc.identifier.citationJornal Brasileiro de Pneumologia. Brasilia Df: Soc Brasileira Pneumologia Tisiologia, v. 40, n. 1, p. 46-54, 2014.
dc.identifier.fileWOS000331594000007.pdf
dc.identifier.issn1806-3713
dc.identifier.lattes4165274708509804
dc.identifier.lattes2620573504503756
dc.identifier.urihttp://hdl.handle.net/11449/112046
dc.identifier.wosWOS:000331594000007
dc.language.isoeng
dc.publisherSoc Brasileira Pneumologia Tisiologia
dc.relation.ispartofJornal Brasileiro de Pneumologia
dc.relation.ispartofjcr1.532
dc.relation.ispartofsjr0,448
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectTobacco smoke pollutionen
dc.subjectEmphysemaen
dc.subjectDisease models, animalen
dc.subjectEquipment and suppliesen
dc.titleA new experimental model of cigarette smoke-induced emphysema in Wistar ratsen
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Pneumologia Tisiologia
unesp.author.lattes4165274708509804
unesp.author.lattes2620573504503756[4]
unesp.author.orcid0000-0002-3354-8430[10]
unesp.author.orcid0000-0002-2826-2622[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Letras, Assispt
unesp.departmentCiências Biológicas - FCLASpt

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