5-HT1B receptor in the suprachiasmatic nucleus of the common marmoset (Callithrix jacchus)

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dc.contributor.authorCavalcante, Jeferson S.
dc.contributor.authorde Pontes, Andre L. B.
dc.contributor.authorEngelberth, Rovena C. G. J.
dc.contributor.authorCavalcante, Judney C.
dc.contributor.authorNascimento, Expedito S.
dc.contributor.authorBorda, Janaina S.
dc.contributor.authorPinato, Luciana [UNESP]
dc.contributor.authorCosta, Miriam S. M. O.
dc.contributor.authorde Toledo, Claudio A. B.
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte (UFRN)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:31:45Z
dc.date.available2014-05-20T13:31:45Z
dc.date.issued2011-01-13
dc.description.abstractSerotonin (5-HT) is involved in the fine adjustments at several brain centers including the core of the mammal circadian timing system (CTS) and the hypothalamic suprachiasmatic nucleus (SCN). The SCN receives massive serotonergic projections from the midbrain raphe nuclei, whose inputs are described in rats as ramifying at its ventral portion overlapping the retinohypothalamic and geniculohypothalamic fibers. In the SCN, the 5-HT actions are reported as being primarily mediated by the 5-HT1 type receptor with noted emphasis for 5-HT1B subtype, supposedly modulating the retinal input in a presynaptic way. In this study in a New World primate species, the common marmoset (Callithrix jacchus), we showed the 5-HT1B receptor distribution at the dorsal SCN concurrent with a distinctive location of 5-HT-immunoreactive fibers. This finding addresses to a new discussion on the regulation and synchronization of the circadian rhythms in recent primates. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal do Rio Grande do Norte (UFRN), Dept Physiol, Biosci Ctr, Lab Chronobiol, BR-59072970 Natal, RN, Brazil
dc.description.affiliationSão Paulo State Univ, Speech Language & Hearing Therapy Dept, BR-17525900 Marilia, SP, Brazil
dc.description.affiliationCity Univ São Paulo, Neurosci Lab, BR-03071000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Speech Language & Hearing Therapy Dept, BR-17525900 Marilia, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipPROPESQ-UFRN
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent06/out
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2010.10.070
dc.identifier.citationNeuroscience Letters. Clare: Elsevier B.V., v. 488, n. 1, p. 6-10, 2011.
dc.identifier.doi10.1016/j.neulet.2010.10.070
dc.identifier.fileWOS000286997800002.pdf
dc.identifier.issn0304-3940
dc.identifier.lattes8372363591179624
dc.identifier.urihttp://hdl.handle.net/11449/10813
dc.identifier.wosWOS:000286997800002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.relation.ispartofjcr2.159
dc.relation.ispartofsjr0,946
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectSuprachiasmatic nucleusen
dc.subjectSerotonin receptoren
dc.subjectCallithrix jacchusen
dc.subjectPrimateen
dc.subjectCircadian timing systemen
dc.subjectSerotoninen
dc.title5-HT1B receptor in the suprachiasmatic nucleus of the common marmoset (Callithrix jacchus)en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes8372363591179624
unesp.author.orcid0000-0001-7788-9205[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Filosofia e Ciências, Maríliapt

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