Rutin ameliorates glycemic index, lipid profile and enzymatic activities in serum, heart and liver tissues of rats fed with a combination of hypercaloric diet and chronic ethanol consumption

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dc.contributor.authorChuffa, Luiz Gustavo A. [UNESP]
dc.contributor.authorFioruci-Fontanelli, Beatriz A. [UNESP]
dc.contributor.authorBordon, Juliana G. [UNESP]
dc.contributor.authorPires, Rafaelle B.
dc.contributor.authorBraga, Camila P. [UNESP]
dc.contributor.authorSeiva, Fabio R. F.
dc.contributor.authorFernandes, Ana Angelica Henrique [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionState Univ North Parana
dc.date.accessioned2015-03-18T15:56:43Z
dc.date.available2015-03-18T15:56:43Z
dc.date.issued2014-06-01
dc.description.abstractAlcoholism and obesity are strongly associated with several disorders including heart and liver diseases. This study evaluated the effects of rutin treatment in serum, heart and liver tissues of rats subjected to a combination of hypercaloric diet (HD) and chronic ethanol consumption. Rats were divided into three groups: Control: rats fed a standard diet and drinking water ad libitum; G1: rats fed the HD and receiving a solution of 10% (v/v) ethanol; and G2: rats fed the HD and ethanol solution, followed by injections of 50 mg/kg(-1) rutin as treatment. After 53 days of HD and ethanol exposure, the rutin was administered every three days for nine days. At the end of the experimental period (95 days), biochemical analyses were carried out on sera, cardiac and hepatic tissues. Body weight gain and food consumption were reduced in both the G1 and G2 groups compared to control animals. Rutin effectively reduced the total lipids (TL), triglycerides (TG), total cholesterol (TC), VLDL, LDL-cholesterol and glucose levels, while it increased the HDL-cholesterol-in the serum of G2 rats, compared to G1. Although rutin had no effect on total protein, albumin, uric acid and cretinine levels, it was able to restore serum activities of alkaline phosphatase (ALP), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatine kinase (CK) in animals fed HD and receiving ethanol. Glycogen stores were replenished in both hepatic and cardiac tissues after rutin treatment. Moreover, rutin consistently reduced hepatic levels of TG and TC and cardiac AST. ALT and CK activities. Thus, rutin treatment was effective in reducing the risk factors for cardiac and hepatic disease caused by both HD and chronic ethanol consumption.en
dc.description.affiliationUniv State Sao Paulo, UNESP, Inst Biosci, Dept Anat, Botucatu, SP, Brazil
dc.description.affiliationUniv State Sao Paulo, UNESP, Botucatu Medial Sch, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Intens Therapy Unit, Bauru, SP, Brazil
dc.description.affiliationUniv State Sao Paulo, UNESP, Inst Biosci, Dept Chem & Biochem, Botucatu, SP, Brazil
dc.description.affiliationState Univ North Parana, Inst Biol, Bandeirantes, PR, Brazil
dc.description.affiliationUnespUniv State Sao Paulo, UNESP, Inst Biosci, Dept Anat, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv State Sao Paulo, UNESP, Botucatu Medial Sch, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv State Sao Paulo, UNESP, Inst Biosci, Dept Chem & Biochem, Botucatu, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent215-222
dc.identifierhttp://nopr.niscair.res.in/bitstream/123456789/29087/1/IJBB%2051%283%29%20215-222.pdf
dc.identifier.citationIndian Journal Of Biochemistry & Biophysics. New Delhi: Natl Inst Science Communication-niscair, v. 51, n. 3, p. 215-222, 2014.
dc.identifier.issn0301-1208
dc.identifier.urihttp://hdl.handle.net/11449/117667
dc.identifier.wosWOS:000340581700006
dc.language.isoeng
dc.publisherNatl Inst Science Communication-niscair
dc.relation.ispartofIndian Journal Of Biochemistry & Biophysics
dc.relation.ispartofjcr0.385
dc.relation.ispartofsjr0,372
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectRutinen
dc.subjectHypercaloric dieten
dc.subjectEthanolen
dc.subjectHearten
dc.subjectLiveren
dc.subjectRaten
dc.titleRutin ameliorates glycemic index, lipid profile and enzymatic activities in serum, heart and liver tissues of rats fed with a combination of hypercaloric diet and chronic ethanol consumptionen
dc.typeArtigo
dcterms.rightsHolderNatl Inst Science Communication-niscair
unesp.author.orcid0000-0002-7461-8773[6]
unesp.author.orcid0000-0002-0199-3396[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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