Association between echocardiographic structural parameters and body weight in Wistar rats

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dc.contributor.authorOliveira-Junior, Silvio A.
dc.contributor.authorMartinez, Paula F.
dc.contributor.authorFan, William Y.C. [UNESP]
dc.contributor.authorNakatani, Bruno T. [UNESP]
dc.contributor.authorPagan, Luana U. [UNESP]
dc.contributor.authorPadovani, Carlos R. [UNESP]
dc.contributor.authorCicogna, Antonio C. [UNESP]
dc.contributor.authorOkoshi, Marina P. [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.institutionFederal University of Mato Grosso do Sul
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:32:11Z
dc.date.available2018-12-11T17:32:11Z
dc.date.issued2017-01-01
dc.description.abstractBackground: The association between echocardiographic structural parameters and body weight (BW) during rat development has been poorly addressed. We evaluated echocardiographic variables: left ventricular (LV) end-diastolic (LVDD) and end-systolic (LVSD) diameters, LV diastolic posterior wall thickness (PWT), left atrial diameter (LA), and aortic diameter (AO) in function of BW during development. Results/Materials and Methods: Male Wistar rats (n = 328, BW: 302-702 g) were retrospectively used to construct regression models and 95% confidence intervals relating to cardiac structural parameters and BW. Adjusted indexes were significant to all relationships; the regression model for predicting LVDD (R2 = 0.678; p < 0.001) and AO (R2 = 0.567; p < 0.001) had the highest prediction coefficients and LA function the lowest prediction coefficient (R2 = 0.274; p < 0.01). These relationships underwent validation by performing echocardiograms on additional rats (n = 43, BW: 300-600 g) and testing whether results were within confidence intervals of our regressions. Prediction models for AO and LA correctly allocated 38 (88.4%) and 39 rats (90.7%), respectively, within the 95% confidence intervals. Regression models for LVDD, LVSD, and PWT included 27 (62.7%), 30 (69.8%), and 19 (44.2%) animals, respectively, within the 95% confidence intervals. Conclusions: Increase in cardiac structures is associated with BW gain during rat growth. LA and AO can be correctly predicted using regression models; prediction of PWT and LV diameters is not accurate.en
dc.description.affiliationSchool of Physical Therapy Federal University of Mato Grosso do Sul
dc.description.affiliationBotucatu Medical School Sao Paulo State University UNESP
dc.description.affiliationBotucatu Biosciences Institute Sao Paulo State University UNESP
dc.description.affiliationUnespBotucatu Medical School Sao Paulo State University UNESP
dc.description.affiliationUnespBotucatu Biosciences Institute Sao Paulo State University UNESP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 308674/2015-4
dc.format.extent26100-26105
dc.identifierhttp://dx.doi.org/10.18632/oncotarget.15320
dc.identifier.citationOncotarget, v. 8, n. 16, p. 26100-26105, 2017.
dc.identifier.doi10.18632/oncotarget.15320
dc.identifier.issn1949-2553
dc.identifier.lattes1590971576309420
dc.identifier.orcid0000-0001-8980-8839
dc.identifier.scopus2-s2.0-85017519922
dc.identifier.urihttp://hdl.handle.net/11449/178804
dc.language.isoeng
dc.relation.ispartofOncotarget
dc.relation.ispartofsjr1,942
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCardiac structures
dc.subjectDevelopment
dc.subjectEchocardiogram
dc.subjectPhysiological cardiac remodeling
dc.subjectRat
dc.titleAssociation between echocardiographic structural parameters and body weight in Wistar ratsen
dc.typeArtigo
unesp.author.lattes1590971576309420
unesp.author.lattes9418970103564137[7]
unesp.author.lattes8727897080522289[6]
unesp.author.orcid0000-0001-8980-8839
unesp.author.orcid0000-0002-4402-6523[7]
unesp.author.orcid0000-0002-7719-9682[6]

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Artigos - Bioestatística - IBB
Artigos - Clínica Médica - FMB