Antagonism produced by hypertonic nutrient solutions on the depressive effect of carbofuran on isolated guinea pig atria

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dc.contributor.authorNascimento, D. C.
dc.contributor.authorSakate, M.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:27:59Z
dc.date.available2014-05-20T15:27:59Z
dc.date.issued1996-04-01
dc.description.abstractThe action of hyperosmotic nutrient solutions on the depressive effects of carbofuran was studied on spontaneously contracting guinea pig atria. The force and frequency of contraction were recorded using an isotonic lever. Carbofuran 33.0 mu g ml(-1) produced a gradual depressive effect. The time for stabilization of the depressive effect was 6.0+/-2.3 min. After the depressive effect of carbofuran was established, NaCI, mannitol, or urea were introduced into the organ bath to increase the osmolarity of the nutrient solution to about 100 mosmol kg(-1) of water. This resulted in a reversal of the contraction force and frequency to the initial levels. The addition of the osmotic agents at the same concentrations before the addition of 33.0 mu g ml(-1) carbofuran avoided its depressive effect on guinea pig atria. (C) 1996 the Italian Pharmacological Society.en
dc.description.affiliationUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,INST BIOSCI BOTUCATU,DEPT PHARMACOL,BR-18618000 BOTUCATU,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,INST BIOSCI BOTUCATU,DEPT PHARMACOL,BR-18618000 BOTUCATU,SP,BRAZIL
dc.format.extent251-254
dc.identifierhttp://dx.doi.org/10.1006/phrs.1996.0035
dc.identifier.citationPharmacological Research. London: Academic Press Ltd, v. 33, n. 4-5, p. 251-254, 1996.
dc.identifier.doi10.1006/phrs.1996.0035
dc.identifier.issn1043-6618
dc.identifier.urihttp://hdl.handle.net/11449/37902
dc.identifier.wosWOS:A1996VR46900006
dc.language.isoeng
dc.publisherAcademic Press Ltd
dc.relation.ispartofPharmacological Research
dc.relation.ispartofjcr4.897
dc.relation.ispartofsjr1,811
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcarbofuranpt
dc.subjecthypertonic solutionpt
dc.subjectsodium chloridept
dc.subjectmannitolpt
dc.subjectureapt
dc.subjectguinea pig atriapt
dc.titleAntagonism produced by hypertonic nutrient solutions on the depressive effect of carbofuran on isolated guinea pig atriaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderAcademic Press Ltd
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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