Antagonism produced by hypertonic nutrient solutions on the depressive effect of carbofuran on isolated guinea pig atria
dc.contributor.author | Nascimento, D. C. | |
dc.contributor.author | Sakate, M. | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T15:27:59Z | |
dc.date.available | 2014-05-20T15:27:59Z | |
dc.date.issued | 1996-04-01 | |
dc.description.abstract | The action of hyperosmotic nutrient solutions on the depressive effects of carbofuran was studied on spontaneously contracting guinea pig atria. The force and frequency of contraction were recorded using an isotonic lever. Carbofuran 33.0 mu g ml(-1) produced a gradual depressive effect. The time for stabilization of the depressive effect was 6.0+/-2.3 min. After the depressive effect of carbofuran was established, NaCI, mannitol, or urea were introduced into the organ bath to increase the osmolarity of the nutrient solution to about 100 mosmol kg(-1) of water. This resulted in a reversal of the contraction force and frequency to the initial levels. The addition of the osmotic agents at the same concentrations before the addition of 33.0 mu g ml(-1) carbofuran avoided its depressive effect on guinea pig atria. (C) 1996 the Italian Pharmacological Society. | en |
dc.description.affiliation | UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,INST BIOSCI BOTUCATU,DEPT PHARMACOL,BR-18618000 BOTUCATU,SP,BRAZIL | |
dc.description.affiliationUnesp | UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,INST BIOSCI BOTUCATU,DEPT PHARMACOL,BR-18618000 BOTUCATU,SP,BRAZIL | |
dc.format.extent | 251-254 | |
dc.identifier | http://dx.doi.org/10.1006/phrs.1996.0035 | |
dc.identifier.citation | Pharmacological Research. London: Academic Press Ltd, v. 33, n. 4-5, p. 251-254, 1996. | |
dc.identifier.doi | 10.1006/phrs.1996.0035 | |
dc.identifier.issn | 1043-6618 | |
dc.identifier.uri | http://hdl.handle.net/11449/37902 | |
dc.identifier.wos | WOS:A1996VR46900006 | |
dc.language.iso | eng | |
dc.publisher | Academic Press Ltd | |
dc.relation.ispartof | Pharmacological Research | |
dc.relation.ispartofjcr | 4.897 | |
dc.relation.ispartofsjr | 1,811 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | carbofuran | pt |
dc.subject | hypertonic solution | pt |
dc.subject | sodium chloride | pt |
dc.subject | mannitol | pt |
dc.subject | urea | pt |
dc.subject | guinea pig atria | pt |
dc.title | Antagonism produced by hypertonic nutrient solutions on the depressive effect of carbofuran on isolated guinea pig atria | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Academic Press Ltd | |
unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatu | pt |
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