Formulating SLN and NLC as innovative drug delivery systems for non-invasive routes of drug administration

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dc.contributor.authorFonseca-Santos, Bruno [UNESP]
dc.contributor.authorSilva, Patrícia Bento
dc.contributor.authorRigon, Roberta Balasin
dc.contributor.authorSato, Mariana Rillo [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity ofBrasília (UnB)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2020-12-12T02:13:52Z
dc.date.available2020-12-12T02:13:52Z
dc.date.issued2020-01-01
dc.description.abstractColloidal carriers diverge depending on their composition, ability to incorporate drugs and applicability, but the common feature is the small average particle size. Among the carriers with the potential nanostructured drug delivery application there are SLN and NLC. These nanostructured systems consist of complex lipids and highly purified mixtures of glycerides having varying particle size. Also, these systems have shown physical stability, protection capacity of unstable drugs, release control ability, excellent tolerability, possibility of vectorization, and no reported production problems related to large-scale. Several production procedures can be applied to achieve high asso-ciation efficiency between the bioactive and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. The whole set of unique advantages such as enhanced drug loading capacity, prevention of drug expulsion, leads to more flexibility for modulation of drug release and makes Lipid-based nanocarriers (LNCs) versatile delivery system for various routes of administration. The route of administration has a significant impact on the therapeutic outcome of a drug. Thus, the non-invasive routes, which were of minor importance as parts of drug delivery in the past, have assumed added importance drugs, proteins, peptides and biopharmaceuticals drug delivery and these include nasal, buccal, vaginal and transdermal routes. The objective of this paper is to present the state of the art concerning the application of the lipid nanocarriers designated for non-invasive routes of administration. In this manner, this review pre-sents an innovative technological platform to develop nanostructured delivery systems with great versatility of application in non-invasive routes of administration and targeting drug release.en
dc.description.affiliationSão Paulo State University-UNESP School of Pharmaceutical Sciences Department of Drugs and Medicines
dc.description.affiliationUniversity ofBrasília (UnB) Department of Genetics and Morphology
dc.description.affiliationUniversity of Campinas (UNICAMP) Faculty of Pharmaceutical Sciences
dc.description.affiliationUnespSão Paulo State University-UNESP School of Pharmaceutical Sciences Department of Drugs and Medicines
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 13/09265-7
dc.description.sponsorshipIdFAPESP: 13/21500-1
dc.description.sponsorshipIdFAPESP: 14/24180-0
dc.description.sponsorshipIdFAPESP: 15/05394-2
dc.description.sponsorshipIdFAPESP: 16/11198-4
dc.format.extent3623-3656
dc.identifierhttp://dx.doi.org/10.2174/0929867326666190624155938
dc.identifier.citationCurrent Medicinal Chemistry, v. 27, n. 22, p. 3623-3656, 2020.
dc.identifier.doi10.2174/0929867326666190624155938
dc.identifier.issn1875-533X
dc.identifier.issn0929-8673
dc.identifier.scopus2-s2.0-85087465028
dc.identifier.urihttp://hdl.handle.net/11449/200706
dc.language.isoeng
dc.relation.ispartofCurrent Medicinal Chemistry
dc.sourceScopus
dc.subjectColloidal carriers
dc.subjectLipid-based nanocarriers (LNCs)
dc.subjectNanostructured lipid carriers (NLC)
dc.subjectNanostructured systems
dc.subjectNon-invasive routes of administration
dc.subjectSolid lipid nanoparticles (SLN)
dc.titleFormulating SLN and NLC as innovative drug delivery systems for non-invasive routes of drug administrationen
dc.typeResenha

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