A study of actinic cheilitis treatment by two low-morbidity CO(2) laser vaporization one-pass protocols

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dc.contributor.authorGodoy Peres, Flavio Francisco de
dc.contributor.authorBrandão, Adriana Aigotti Haberbeck [UNESP]
dc.contributor.authorCarvalho, Yasmin Rodarte [UNESP]
dc.contributor.authorDoria Filho, Ulysses
dc.contributor.authorPlapler, Helio
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSão Paulo Fed Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T14:04:33Z
dc.date.available2014-05-20T14:04:33Z
dc.date.issued2009-05-01
dc.description.abstractTherapeutic approaches to chronic actinic cheilitis focus on the removal or destruction of diseased epithelium. The CO(2) laser has become an important therapeutic alternative, achieving clinical resolution in around 90% of patients. Although many laser physical parameters have been reported, some are known for their low potential for scar induction without compromising the success of the results. The aim of this clinicohistological study was to compare the therapeutic responses to two low-morbidity protocols involving a single laser pass. A total of 40 patients with chronic multicentric and microscopically proven disease were randomly submitted to two conservative CO(2) laser protocols using a bilateral comparative model. The degree of histological atypia of the epithelium was determined in 26 patients both pre- and postoperatively for both protocols. Other histological phenomena were assessed in addition to this central analysis parameter. Clinical recurrence occurred in 12.5% of patients for each protocol, together with a significant reduction in the degree of epithelial atypia (p < 0.001), which was occasionally complete. However, no difference was found between the protocols (p > 0.05). Using these morphological parameters it was not possible to determine whether postoperative epithelial atypias in part of the sample were reactive or residual in nature. A few patients may show minor postoperative lesions. Due to their potential to achieve clinical and importantly microscopic resolution, the studied protocols may be used for mild through moderate dysplastic epithelium and clinically diffuse disease.en
dc.description.affiliationUniv Fed São Paulo, Dept Cirurgia, Disciplina Tecn Operatoria & Cirurgia Expt, BR-04023900 São Paulo, Brazil
dc.description.affiliationSão Paulo Fed Univ, UNIFESP, Grad Program Surg & Experimentat, Discipline Operat Tech & Expt Surg,Dept Surg,Med, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Discipline Oral Pathol, Dept Biosci & Oral Diag,Dent Sch, Sao Jose Dos Campos, Brazil
dc.description.affiliationUniv São Paulo, Dept Biostat, Inst Child, Sch Med, BR-09500900 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Discipline Oral Pathol, Dept Biosci & Oral Diag,Dent Sch, Sao Jose Dos Campos, Brazil
dc.format.extent375-385
dc.identifierhttp://dx.doi.org/10.1007/s10103-008-0574-y
dc.identifier.citationLasers In Medical Science. Artington: Springer London Ltd, v. 24, n. 3, p. 375-385, 2009.
dc.identifier.doi10.1007/s10103-008-0574-y
dc.identifier.issn0268-8921
dc.identifier.lattes6967369119792151
dc.identifier.urihttp://hdl.handle.net/11449/22650
dc.identifier.wosWOS:000265499300012
dc.language.isoeng
dc.publisherSpringer London Ltd
dc.relation.ispartofLasers in Medical Science
dc.relation.ispartofjcr1.949
dc.relation.ispartofsjr0,713
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectActinic cheilitisen
dc.subjectOral precanceren
dc.subjectLaser surgeryen
dc.subjectOral epithelial dysplasiaen
dc.subjectHistopathologyen
dc.titleA study of actinic cheilitis treatment by two low-morbidity CO(2) laser vaporization one-pass protocolsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer London Ltd
unesp.author.lattes6967369119792151
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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