Central interaction between atrial natriuretic peptide and angiotensin II in the control of sodium intake and excretion in female rats

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dc.contributor.authorDe-Angelis, P. R. [UNESP]
dc.contributor.authorAntunes, V. R. [UNESP]
dc.contributor.authorCamargo, G. M.P.A. [UNESP]
dc.contributor.authorSaad, W. A. [UNESP]
dc.contributor.authorRenzi, A. [UNESP]
dc.contributor.authorCamargo, L. A.A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:54:22Z
dc.date.available2022-04-28T19:54:22Z
dc.date.issued1996-12-23
dc.description.abstractWe investigated the effects of estrogen on sodium intake and excretion induced by angiotensin II (ANG II), atrial natriuretic peptide (ANP) or ANG II plus ANP injected into the median preoptic nucleus (MnPO). Female Holtzman rats weighing 250-300 g were used. Sodium ingestion and excretion 120 min after the injection of 0.5 μl of 0.15 M NaCl into the MnPO were 0.3 ± 0.1 ml (N = 12) and 29 ± 7 μEq in intact rats, 0.5 ± 0.2 ml (N = 10) and 27 ± 6 μEq in ovariectomized rats, and 0.2 ± 0.08 (N = 11) and 36 ± 8 μEq in estrogen-treated ovariectomized (50 μg/day for 21 days) rats, respectively. ANG II (21 μM) injection in intact, ovariectomized, and estrogen-treated ovariectomized rats increased sodium intake (3.8 ± 0.4, 1.8 ± 0.3 and 1.2 ± 0.2 ml/120 min, respectively) (N = 11) and increased sodium excretion (166 ± 18,82 ± 22 and 86 ± 12 μEq/120 min, respectively) (N = 11). ANP (65 μM) injection in intact (N = 11), ovariectomized (N = 10) and estrogen-treated ovariectomzed (N = 10) rats increased sodium intake (1.4 ± 0.2, 1.8 ± 0.3, and 1.7 ± 0.3 ml/120 min, respectively) and sodium excretion (178 ± 19, 187 ± 9, and 232 ± 29 μEq/120 min, respectively). Concomitant injection of ANG II and ANP into the MnPO of intact (N = 12), ovariectomized (N = 10) and estrogen-treated ovariectomized (N = 10) rats caused smaller effects than those produced by each peptide given alone: 1.3 ± 0.2, 0.9 ± 0.2 and 0.3 ± 0.1 ml/120 min for sodium intake, respectively, and 86 ± 9,58 ± 7, and 22 ± 4 μEq/120 min for sodium excretion, respectively. Taken together, these results demonstrate that there is an antagonistic interaction of ANP and ANG II on sodium intake and excretion, and that reproductive hormones affect this interaction.en
dc.description.affiliationDepto. de Ciê. Fisiol. Faculdadede Odontologia Universidade Estadual Paulista, 14801-903 Araraquara, SP
dc.description.affiliationDepto. de Ciê. Fisiol. Faculdade de Odontologia Universidade Estadual Paulista, Rua Humailá, 1680, 14801-903 Araraquara, SP
dc.description.affiliationUnespDepto. de Ciê. Fisiol. Faculdadede Odontologia Universidade Estadual Paulista, 14801-903 Araraquara, SP
dc.description.affiliationUnespDepto. de Ciê. Fisiol. Faculdade de Odontologia Universidade Estadual Paulista, Rua Humailá, 1680, 14801-903 Araraquara, SP
dc.format.extent1671-1674
dc.identifier.citationBrazilian Journal of Medical and Biological Research, v. 29, n. 12, p. 1671-1674, 1996.
dc.identifier.issn0100-879X
dc.identifier.scopus2-s2.0-0029902829
dc.identifier.urihttp://hdl.handle.net/11449/224028
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.sourceScopus
dc.subjectangiotensin II
dc.subjectatrial natriuretic peptide
dc.subjectovariectomy
dc.subjectsodium excretion
dc.subjectsodium intake
dc.titleCentral interaction between atrial natriuretic peptide and angiotensin II in the control of sodium intake and excretion in female ratsen
dc.typeArtigo

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