The possible involvement of hyperpolarizing mechanisms in histamine-induced relaxation of the rat portal vein

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dc.contributor.authorRossignoli, Patrícia de S. [UNESP]
dc.contributor.authorRodrigues, Andréa D.
dc.contributor.authorTinti, Thaís
dc.contributor.authorPereira, Oduvaldo C. M. [UNESP]
dc.contributor.authorEllinger, Fred
dc.contributor.authorChies, Agnaldo B.
dc.contributor.institutionFaculty of Medicine of Marília
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:23:41Z
dc.date.available2014-05-27T11:23:41Z
dc.date.issued2008-11-07
dc.description.abstractThe present study evaluated the effects of histamine 10 -2 M on longitudinal preparations of rat portal vein. It was observed that histamine 10 -2 M induced relaxation of rat portal vein preparations pre-contracted with phenylephrine 10 -4 M. On the other hand, no pharmacological effects were observed in preparations not pre-contracted. The observed histamine-induced relaxing effect was absent in preparations pre-contracted with KCl (120 mM) or in the presence of depolarizing nutritive solution. However, the histamine-induced relaxation was still present in the endothelium-removed preparations. The histamine-induced relaxation also was not prevented by astemizole (10 -6 M, 10 -5 M and 10 -4 M), cimetidine (10 -5 M, 10 -4 M and 10 -3 M) or thioperamide (10 -6 M, 10 -5 M and 10 -4 M), selective antagonists H 1, H 2 and H 3, respectively. The presence of L-NAME 10 -4 M or L-NAME 10 -4 M plus indomethacin 10 -5 M also did not prevent the histamine-induced relaxation observed in rat portal vein. Thus, the histamine-induced relaxation observed in rat portal vein appears to involve a non-endothelial hyperpolarizing mechanism independent of H 1, H 2 and H 3 receptors.en
dc.description.affiliationLaboratory of Pharmacology Faculty of Medicine of Marília
dc.description.affiliationDepartment of Pharmacology Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationLaboratory of Pathology Faculty of Medicine of Marília
dc.description.affiliationLaboratory of Pharmacology Faculty of Medicine of Marília, Monte Carmelo 800, Fragata 17, 519-030, Marília, São Paulo
dc.description.affiliationUnespDepartment of Pharmacology Institute of Biosciences São Paulo State University (UNESP)
dc.format.extent129-141
dc.identifierhttp://dx.doi.org/10.1540/jsmr.44.12
dc.identifier.citationJournal of Smooth Muscle Research, v. 44, n. 3-4, p. 129-141, 2008.
dc.identifier.doi10.1540/jsmr.44.12
dc.identifier.file2-s2.0-55249108921.pdf
dc.identifier.issn0916-8737
dc.identifier.lattes2622975453563085
dc.identifier.orcid0000-0001-6946-1145
dc.identifier.scopus2-s2.0-55249108921
dc.identifier.urihttp://hdl.handle.net/11449/70630
dc.language.isoeng
dc.relation.ispartofJournal of Smooth Muscle Research
dc.relation.ispartofsjr0,225
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectEndothelium
dc.subjectHistamine
dc.subjectHyperpolarizing mechanism
dc.subjectPortal vein
dc.subjectRelaxation
dc.subjectastemizole
dc.subjectenzyme inhibitor
dc.subjecthistamine
dc.subjecthistamine agonist
dc.subjecthistamine H1 receptor
dc.subjecthistamine H1 receptor antagonist
dc.subjectn(g) nitroarginine methyl ester
dc.subjectphenylephrine
dc.subjectpotassium chloride
dc.subjectvasoconstrictor agent
dc.subjectanimal
dc.subjectanimal model
dc.subjectdose response
dc.subjectdrug effect
dc.subjectmale
dc.subjectphysiology
dc.subjectportal vein
dc.subjectrat
dc.subjectvasodilatation
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectAstemizole
dc.subjectDose-Response Relationship, Drug
dc.subjectEnzyme Inhibitors
dc.subjectHistamine Agonists
dc.subjectHistamine H1 Antagonists, Non-Sedating
dc.subjectMale
dc.subjectModels, Animal
dc.subjectNG-Nitroarginine Methyl Ester
dc.subjectPhenylephrine
dc.subjectPortal Vein
dc.subjectPotassium Chloride
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Histamine H1
dc.subjectVasoconstrictor Agents
dc.subjectVasodilation
dc.titleThe possible involvement of hyperpolarizing mechanisms in histamine-induced relaxation of the rat portal veinen
dc.typeArtigo
unesp.author.lattes2622975453563085[1]
unesp.author.orcid0000-0001-6946-1145[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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