Antiviral Activity of Quercetin Hydrate against Zika Virus

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dc.contributor.authorSaivish, Marielena Vogel
dc.contributor.authorMenezes, Gabriela de Lima
dc.contributor.authorda Silva, Roosevelt Alves
dc.contributor.authorFontoura, Marina Alves
dc.contributor.authorShimizu, Jacqueline Farinha
dc.contributor.authorda Silva, Gislaine Celestino Dutra
dc.contributor.authorTeixeira, Igor da Silva
dc.contributor.authorMistrão, Natalia Franco Bueno
dc.contributor.authorHernandes, Victor Miranda
dc.contributor.authorRahal, Paula [UNESP]
dc.contributor.authorSacchetto, Lívia
dc.contributor.authorPacca, Carolina Colombelli [UNESP]
dc.contributor.authorMarques, Rafael Elias
dc.contributor.authorNogueira, Maurício Lacerda
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto
dc.contributor.institutionCentro Nacional de Pesquisa em Energia e Materiais (CNPEM)
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte
dc.contributor.institutionUniversidade Federal de Jataí
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFaceres Medical School
dc.contributor.institutionThe University of Texas Medical Branch
dc.date.accessioned2023-07-29T13:53:18Z
dc.date.available2023-07-29T13:53:18Z
dc.date.issued2023-04-01
dc.description.abstractZika virus (ZIKV) has re-emerged in recent decades, leading to outbreaks of Zika fever in Africa, Asia, and Central and South America. Despite its drastic re-emergence and clinical impact, no vaccines or antiviral compounds are available to prevent or control ZIKV infection. This study evaluated the potential antiviral activity of quercetin hydrate against ZIKV infection and demonstrated that this substance inhibits virus particle production in A549 and Vero cells under different treatment conditions. In vitro antiviral activity was long-lasting (still observed 72 h post-infection), suggesting that quercetin hydrate affects multiple rounds of ZIKV replication. Molecular docking indicates that quercetin hydrate can efficiently interact with the specific allosteric binding site cavity of the NS2B-NS3 proteases and NS1-dimer. These results identify quercetin as a potential compound to combat ZIKV infection in vitro.en
dc.description.affiliationLaboratório de Pesquisas em Virologia Departamento de Doenças Dermatológicas Infecciosas e Parasitárias Faculdade de Medicina de São José do Rio Preto, SP
dc.description.affiliationBrazilian Biosciences National Laboratory Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), SP
dc.description.affiliationDepartamento de Biofísica e Farmacologia Universidade Federal do Rio Grande do Norte, RN
dc.description.affiliationUnidade Especial de Ciências Exatas Universidade Federal de Jataí, GO
dc.description.affiliationLaboratório de Estudos Genômicos Departamento de Biologia Instituto de Biociências Letras e Ciências Exatas Universidade Estadual Paulista, SP
dc.description.affiliationDepartamento de Microbiologia Faceres Medical School, SP
dc.description.affiliationDepartment of Pathology The University of Texas Medical Branch
dc.description.affiliationUnespLaboratório de Estudos Genômicos Departamento de Biologia Instituto de Biociências Letras e Ciências Exatas Universidade Estadual Paulista, SP
dc.identifierhttp://dx.doi.org/10.3390/ijms24087504
dc.identifier.citationInternational Journal of Molecular Sciences, v. 24, n. 8, 2023.
dc.identifier.doi10.3390/ijms24087504
dc.identifier.issn1422-0067
dc.identifier.issn1661-6596
dc.identifier.scopus2-s2.0-85156225689
dc.identifier.urihttp://hdl.handle.net/11449/248773
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.sourceScopus
dc.subjectantiviral activity
dc.subjectin silico analysis
dc.subjectinhibition
dc.subjectnatural products
dc.subjectZika virus
dc.titleAntiviral Activity of Quercetin Hydrate against Zika Virusen
dc.typeArtigo
unesp.author.orcid0000-0002-7627-621X[1]
unesp.author.orcid0000-0002-8944-8148[2]
unesp.author.orcid0000-0001-5624-4790[3]
unesp.author.orcid0000-0002-1192-7210[4]
unesp.author.orcid0000-0001-7424-4014[7]
unesp.author.orcid0000-0001-9716-6899[11]
unesp.author.orcid0000-0002-6949-0947[13]
unesp.author.orcid0000-0003-1102-2419[14]

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Artigos - Biologia - IBILCE