Quantitative trait loci with sex-specific effects for internal organs weights and hematocrit value in a broiler-layer cross

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dc.contributor.authorMoura, A. S. A. M. T. [UNESP]
dc.contributor.authorLedur, M. C.
dc.contributor.authorBoschiero, C.
dc.contributor.authorNones, K.
dc.contributor.authorPinto, L. F. B.
dc.contributor.authorJaenisch, F. R. F.
dc.contributor.authorBurt, D. W.
dc.contributor.authorCoutinho, L. L.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionQIMR Berghofer Medical Research Istitute, 300 Herston Road, Brisbane, QLD, 4006, Australia.
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionDivision of Genetics and Genomics, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, EH25 9PS, UK.
dc.date.accessioned2015-12-07T15:39:45Z
dc.date.available2015-12-07T15:39:45Z
dc.date.issued2015-10-24
dc.description.abstractRapid growth in broilers is associated with susceptibility to metabolic disorders such as pulmonary hypertension syndrome (ascites) and sudden death. This study describes a genome search for QTL associated with relative weight of cardio respiratory and metabolically important organs (heart, lungs, liver and gizzard), and hematocrit value in a Brazilian broiler-layer cross. QTL with similar or different effects across sexes were investigated. At 42 days of age after fasted for 6 h, the F2 chickens were weighed and slaughtered. Weights and percentages of the weight relative to BW42 of gizzard, heart, lungs, liver and hematocrit were used in the QTL search. Parental, F1 and F2 individuals were genotyped with 128 genetic markers (127 microsatellites and 1 SNP) covering 22 linkage groups. QTL mapping analyses were carried out using mixed models. A total of 11 genome-wide significant QTL and five suggestive linkages were mapped. Thus, genome-wide significant QTL with similar effects across sexes were mapped to GGA2, 4 and 14 for heart weight, and to GGA2, 8 and 12 for gizzard %. Additionally, five genome-wide significant QTL with different effects across sexes were mapped to GGA 8, 19 and 26 for heart weight; GGA26 for heart % and GGA3 for hematocrit value. Five QTL were detected in chromosomal regions where QTL for similar traits were previously mapped in other F2 chicken populations. Seven novel genome-wide significant QTL are reported here, and 21 positional candidate genes in QTL regions were identified.en
dc.description.affiliationDepartamento de Produção Animal, Universidade Estadual Paulista - UNESP/FMVZ, Botucatu, SP, 18618-970, Brazil. anamoura@fmvz.unesp.br.
dc.description.affiliation, Embrapa Suínos e Aves, C.P. 21, Concórdia, SC, 89700-000, Brazil.
dc.description.affiliationDepartamento de Zootecnia, USP/ESALQ, C.P. 09, Piracicaba, SP, 13418-900, Brazil.
dc.description.affiliationQIMR Berghofer Medical Research Istitute, 300 Herston Road, Brisbane, QLD, 4006, Australia.
dc.description.affiliationDepartamento de Zootecnia, Universidade Federal da Bahia, Salvador, BA, Brazil.
dc.description.affiliationDivision of Genetics and Genomics, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, EH25 9PS, UK.
dc.description.affiliationUnespDepartamento de Produção Animal, Universidade Estadual Paulista - UNESP/FMVZ, Botucatu, SP, 18618-970, Brazil. anamoura@fmvz.unesp.br.
dc.identifierhttp://dx.doi.org/10.1007/s13353-015-0325-2
dc.identifier.citationJournal Of Applied Genetics, 2015.
dc.identifier.doi10.1007/s13353-015-0325-2
dc.identifier.issn2190-3883
dc.identifier.pubmed26496990
dc.identifier.urihttp://hdl.handle.net/11449/131661
dc.language.isoeng
dc.publisherJournal Of Applied Genetics
dc.relation.ispartofJournal Of Applied Genetics
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectCandidate geneen
dc.subjectGizzarden
dc.subjectHearten
dc.subjectLiveren
dc.subjectMicrosatellite markeren
dc.titleQuantitative trait loci with sex-specific effects for internal organs weights and hematocrit value in a broiler-layer crossen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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