Vital bone formation after grafting of autogenous bone and biphasic calcium phosphate bioceramic in extraction sockets of rats: Histological, histometric, and immunohistochemical evaluation

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dc.contributor.authorMacedo, Rander Moreira
dc.contributor.authorLacerda, Suzie Aparecida
dc.contributor.authorOkamoto, Roberta [UNESP]
dc.contributor.authorShahdad, Shakeel
dc.contributor.authorBrentegani, Luiz Guilherme
dc.contributor.institutionPositivo University
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionBarts and the London NHS Trust
dc.contributor.institutionBarts and the London School of Medicine and Dentistry
dc.contributor.institutionInternational Team for Implantology (ITI) UK and Ireland Section
dc.date.accessioned2019-10-06T16:06:48Z
dc.date.available2019-10-06T16:06:48Z
dc.date.issued2018-01-01
dc.description.abstractPurpose: The study aimed to investigate through histology, histometry, and immunohistochemistry the vital bone formation after grafting of biphasic calcium phosphate bioceramic (BC) in combination with calvarial autogenous bone into the dental sockets of rats. Materials and Methods: Fortyfive male rats were submitted to upper right incisor extraction and divided according to the grafted material in: control, bioceramic (BC), and bioceramic + autogenous bone (BC + AB). The animals were killed 7, 21, and 42 days after surgery for histological, histometric, and immunohistochemistry analysis. Results: Histomorphometric results demonstrated, for BC + AB group, formation of trabecular bone between the particles of BCs and autogenous bone, connecting them, as well as higher percentage of vital bone in comparison with BC. Immunohistochemical reactions showed intense labeling for Runx2-positive cells in the group BC + AB. Conclusions: Autogenous bone was able to stimulate bone turnover enabling a larger amount of vital bone synthesis and can be recommended as a viable grafting material in combination with synthetic biphasic BC.en
dc.description.affiliationDepartment of Dentistry Positivo University
dc.description.affiliationDepartment of Stomatology Public Health and Forensic Dentistry School of Dentistry of Ribeirão Preto USP - University of São Paulo
dc.description.affiliationDepartment of Basic Sciences School of Dentistry of Aracatuba UNESP Universidade Estadual Paulista
dc.description.affiliationRoyal London Dental Hospital Department of Restorative Dentistry Barts and the London NHS Trust
dc.description.affiliationQueen Mary University of London Barts and the London School of Medicine and Dentistry
dc.description.affiliationInternational Team for Implantology (ITI) UK and Ireland Section
dc.description.affiliationUnespDepartment of Basic Sciences School of Dentistry of Aracatuba UNESP Universidade Estadual Paulista
dc.format.extent615-622
dc.identifierhttp://dx.doi.org/10.1097/ID.0000000000000815
dc.identifier.citationImplant Dentistry, v. 27, n. 6, p. 615-622, 2018.
dc.identifier.doi10.1097/ID.0000000000000815
dc.identifier.issn1056-6163
dc.identifier.scopus2-s2.0-85057076088
dc.identifier.urihttp://hdl.handle.net/11449/188398
dc.language.isoeng
dc.relation.ispartofImplant Dentistry
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAnimal study
dc.subjectBone graft
dc.subjectBone substitutes
dc.subjectExtraction socket
dc.titleVital bone formation after grafting of autogenous bone and biphasic calcium phosphate bioceramic in extraction sockets of rats: Histological, histometric, and immunohistochemical evaluationen
dc.typeArtigo

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