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Leaf anatomy of Protium ovatum and its antiproliferative potential in cervical cells

dc.contributor.authorRosalem, Patricia F. [UNESP]
dc.contributor.authorPicao, Thais B. [UNESP]
dc.contributor.authorRodrigues-Lisoni, Flavia C. [UNESP]
dc.contributor.authorMartins, Aline R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T17:44:21Z
dc.date.available2018-11-26T17:44:21Z
dc.date.issued2017-11-01
dc.description.abstractThe aim of this study was to analyze the morphology and anatomy of the leaves of Protium ovatum Engl., Burseraceae, and verify the antiproliferative activity in cervical cells. For anatomical analysis, the leaf samples were fixed in formol, acetic acid, alcohol 70, dehydrated, included in hydroxyethyl methacrylate and sectioned at a thickness of 510 mu m in rotative microtome. The samples were stained with toluidine blue and blades mounted with synthetic resin Entellan. Histochemical tests and scanning electron microscopy were also performed. To investigate the antiproliferative effect we used the cells strain of human cervix carcinoma and normal keratinocytes. The anatomical analysis demonstrated that the leaf is hypostomatic and the epidermal cells walls were slightly undulate on both faces. The palisade parenchyma occupies most part of leaf mesophyll. The spongy parenchyma is organized into 34 layers of cells. Vascular bundles of smaller diameter and secretory cavities are distributed along the leaf mesophyll. The midrib region was formed by a single vascular bundle with xylem in the center surrounded by phloem. Secretory cavities are distributed along the phloem. The histochemical tests revealed the presence of lipids in the secretory cavities and phenolic compounds in almost cell of mesophyll. Scanning electron microscopy analysis showed the smooth leaf cuticle ornamentation with some striated areas. It was observed antiproliferative effect on human cervix carcinoma cell comparing with normal cells. (c) 2017 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.en
dc.description.affiliationUniv Estadual Paulista, Dept Biol & Zootecn, Ilha Solteira, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Biol & Zootecn, Ilha Solteira, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2017/021000-3
dc.format.extent673-678
dc.identifierhttp://dx.doi.org/10.1016/j.bjp.2017.09.001
dc.identifier.citationRevista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Curitiba-pr: Soc Brasileira Farmacognosia, v. 27, n. 6, p. 673-678, 2017.
dc.identifier.doi10.1016/j.bjp.2017.09.001
dc.identifier.fileS0102-695X2017000600673.pdf
dc.identifier.issn0102-695X
dc.identifier.scieloS0102-695X2017000600673
dc.identifier.urihttp://hdl.handle.net/11449/163633
dc.identifier.wosWOS:000418069300001
dc.language.isoeng
dc.publisherSoc Brasileira Farmacognosia
dc.relation.ispartofRevista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectMorphology
dc.subjectPlant anatomy
dc.subjectMedicinal plants
dc.subjectAntiproliferative effect
dc.subjectSiHa
dc.titleLeaf anatomy of Protium ovatum and its antiproliferative potential in cervical cellsen
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Farmacognosia
unesp.author.lattes9949448179423191[4]
unesp.author.orcid0000-0002-2931-4981[4]
unesp.departmentBiologia e Zootecnia - FEISpt

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