Fatty acid composition of mid-trimester amniotic fluid in women of different ethnicities

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dc.contributor.authorWitkin, Steven Sol [UNESP]
dc.contributor.authorSkupski, Daniel
dc.contributor.authorHerway, Catherine
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.authorSaito, Felipe [UNESP]
dc.contributor.authorHarris, Mary
dc.contributor.institutionCornell Univ
dc.contributor.institutionNew York Hosp
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionColorado State Univ
dc.date.accessioned2014-05-20T13:35:23Z
dc.date.available2014-05-20T13:35:23Z
dc.date.issued2012-06-01
dc.description.abstractObjective: To determine whether the fatty acid composition of mid-trimester amniotic fluid differs by ethnicity and pregnancy outcome. Methods: Fatty acid composition was analyzed by gas chromatography in 198 women undergoing amniocentesis at 15-19 weeks gestation. Cytokine levels were determined by ELISA in a subgroup of 52 subjects. Results: The major fatty acids detected were palmitic acid (31.8%) and stearic acid (31.5%). The n-6 polyunsaturated fatty acids (PUFA), linoleic acid (LA, 18: 2) and arachidonic acid (AA, 20: 4), were 11.3%, while the n-3 PUFA fatty acids, alpha linolenic acid (ALA, 18: 3) and docosahexaenoic acid (DHA, 22: 6), were 3.8% of the total. Palmitic acid was a higher percentage in Asians (40.5%) and Whites (34.5%) than in Blacks (22.2%) and Hispanics (23.7%) (p <= 0.0012). Oleic acid (18:1 n-9) was a higher percentage in Blacks (12.2%) and Hispanics (12.1%) than in Whites (9.2%) or Asians (7.5%) (<= 0.0002). LA and AA were higher in Blacks (9.0%, 5.4%) and Hispanics (8.6%, 4.1%) than in Whites (6.1%, 3.7%) and Asians (5.5%, 2.9%) (p <= 0.0002). DHA did not differ among the ethnic groups or according to pregnancy outcome. A reduced palmitic acid percentage was identified in the six women with preeclampsia (p = 0.0233). Tumor necrosis factor-alpha levels were inversely proportional to the palmitic acid percentage (p = 0.0275) and positively associated with the percentages of stearic (18:0) (p = 0.0132) and oleic (p = 0.0290) acids. Conclusions: Amniotic fluid fatty acid composition differed among the ethnic groups and may influence inflammatory mediator production and susceptibility to preeclampsia.en
dc.description.affiliationCornell Univ, Div Infect Dis & Immunol, Dept Obstet & Gynecol, Weill Med Coll, New York, NY 10065 USA
dc.description.affiliationNew York Hosp, Dept Obstet & Gynecol, Queens Med Ctr, New York, NY 10021 USA
dc.description.affiliationSão Paulo State Univ, Dept Gynecol & Obstet, Botucatu Med Sch, UNESP, Botucatu, SP, Brazil
dc.description.affiliationColorado State Univ, Dept Food Sci & Human Nutr, Ft Collins, CO 80523 USA
dc.description.affiliationUnespSão Paulo State Univ, Dept Gynecol & Obstet, Botucatu Med Sch, UNESP, Botucatu, SP, Brazil
dc.format.extent818-821
dc.identifierhttp://dx.doi.org/10.3109/14767058.2011.592877
dc.identifier.citationJournal of Maternal-fetal & Neonatal Medicine. London: Informa Healthcare, v. 25, n. 6, p. 818-821, 2012.
dc.identifier.doi10.3109/14767058.2011.592877
dc.identifier.issn1476-7058
dc.identifier.lattes6758680388835078
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.urihttp://hdl.handle.net/11449/12170
dc.identifier.wosWOS:000304097600052
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofJournal of Maternal-fetal & Neonatal Medicine
dc.relation.ispartofjcr1.493
dc.relation.ispartofsjr0,714
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectamniotic fluiden
dc.subjectfatty acidsen
dc.subjectpreeclampsiaen
dc.subjectpregnancy outcomeen
dc.subjecttumor necrosis factor-alphaen
dc.titleFatty acid composition of mid-trimester amniotic fluid in women of different ethnicitiesen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dcterms.rightsHolderInforma Healthcare
unesp.author.lattes6758680388835078
unesp.author.orcid0000-0002-9227-832X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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