Comparison of exfoliative pap stain and AgNOR counts of the tongue in smokers and nonsmokers

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dc.contributor.authorFontes, Patrícia Campos [UNESP]
dc.contributor.authorCorrêa, Gustavo Henrique Marques [UNESP]
dc.contributor.authorIssa, Jaqueline Scholz
dc.contributor.authorBrandão, Adriana Aigotti Haberbeck [UNESP]
dc.contributor.authorAlmeida, Janete Dias [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:23:42Z
dc.date.available2014-05-27T11:23:42Z
dc.date.issued2008-12-01
dc.description.abstractObjective To compare exfoliative cytology from the oral mucosa of smokers and nonsmokers, with emphasis on proliferative activity. Methods Exfoliative cytology specimens were obtained from clinical normal mucosa from the lateral border of the tongue in 30 nonsmokers and 30 smokers ranging in age from 40 to 70 years of age, who were seen at the Heart Institute's Patient Center and the Smoking Cessation Program of the University Hospital, University of São Paulo Medical School (InCor-HCFMUSP). The cytologic specimens were evaluated by Papanicolaou staining and AgNOR quantification in order to evaluate the presence of cytological alterations suggestive of inflammation, dysplasia, keratinization, and proliferative activity of epithelial cells. Results Only Papanicolaou Class I and Class II smears were observed. Inflammatory alterations were found in 90% of smokers and in 87% of nonsmokers. The number of AgNORs/nucleus differed significantly between smokers and nonsmokers (3.372 ± 0.375 versus 2.732 ± 0.236). Conclusions Within the limitations of this research, the results indicate higher proliferative activity in smoking patients compared to nonsmoking patients, even in the absence of clinical lesions. © The Author(s) 2008.en
dc.description.affiliationSão José dos Campos Dental School UNESP-São Paulo State University, São José dos Campos, SP
dc.description.affiliationHeart Institute (InCor) Medical School University of São Paulo, Sao Paulo, SP
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis São José dos Campos Dental School UNESP-São Paulo State University, Av. Francisco José Longo, 777 São Dimas, São José dos Campos, SP 12245-000
dc.description.affiliationUnespSão José dos Campos Dental School UNESP-São Paulo State University, São José dos Campos, SP
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis São José dos Campos Dental School UNESP-São Paulo State University, Av. Francisco José Longo, 777 São Dimas, São José dos Campos, SP 12245-000
dc.format.extent157-162
dc.identifierhttp://dx.doi.org/10.1007/s12105-008-0059-0
dc.identifier.citationHead and Neck Pathology, v. 2, n. 3, p. 157-162, 2008.
dc.identifier.doi10.1007/s12105-008-0059-0
dc.identifier.issn1936-055X
dc.identifier.issn1936-0568
dc.identifier.lattes9514297710569236
dc.identifier.scopus2-s2.0-72849142700
dc.identifier.urihttp://hdl.handle.net/11449/70659
dc.language.isoeng
dc.relation.ispartofHead and Neck Pathology
dc.relation.ispartofsjr0,722
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCytodiagnosis
dc.subjectDisease prevention
dc.subjectNucleolar organizer region
dc.subjectOral mucosa
dc.subjectSmoking
dc.subjectcell nucleus antigen
dc.subjectnucleolar organizer region associated proteins
dc.subjectadult
dc.subjectaged
dc.subjectcell proliferation
dc.subjectchemistry
dc.subjectchromosome NOR
dc.subjectcomparative study
dc.subjectcytodiagnosis
dc.subjectdrug effect
dc.subjecthuman
dc.subjectmale
dc.subjectmetabolism
dc.subjectmethodology
dc.subjectmiddle aged
dc.subjectmouth mucosa
dc.subjectpathology
dc.subjectreproducibility
dc.subjectsilver staining
dc.subjectsmoking
dc.subjectstaining
dc.subjecttongue disease
dc.subjectAdult
dc.subjectAged
dc.subjectAntigens, Nuclear
dc.subjectCell Proliferation
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMouth Mucosa
dc.subjectNucleolus Organizer Region
dc.subjectReproducibility of Results
dc.subjectSilver Staining
dc.subjectStaining and Labeling
dc.subjectTongue Diseases
dc.titleComparison of exfoliative pap stain and AgNOR counts of the tongue in smokers and nonsmokersen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
unesp.author.lattes9514297710569236
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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