Preemptive use of intravenous ibuprofen to reduce postoperative pain after lower third molar surgery: a systematic review of randomized controlled trials

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dc.contributor.authorSilva, Pedro Urquiza Jayme
dc.contributor.authorMeneses-santos, Daniela
dc.contributor.authorVieira, Walbert De Andrade
dc.contributor.authorRamacciato, Juliana Cama
dc.contributor.authorSilva, Ricardo Pedro Da
dc.contributor.authorSilva, Marcelo Caetano Parreira Da
dc.contributor.authorRode, Sigmar De Mello [UNESP]
dc.contributor.authorParanhos, Luiz Renato
dc.contributor.institutionProgram de Pos-Graduacao em Odontologia, Faculdade de Odontologia, Universidade Federal de Uberlandia
dc.contributor.institutionPrograma de Residencia, Departamento de Cirurgia e Traumatologia Buco-Maxilo-Facial, Faculdade de Odontologia, Universidade Federal de Uberlandia
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionDepartamento de Farmacologia, Anestesiologia e Terapeutica, Faculdade de Medicina e Odontologia e Centro de Pesquisas Odontologicas Sao Leopoldo Mandic
dc.contributor.institutionDepartamento de Cirurgia e Traumatologia Buco-Maxilo-Facial, Faculdade de Odontologia, Universidade Federal de Uberlandia (UFU)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionArea de Odontologia Preventiva e Social, Faculdade de Odontologia, Universidade Federal de Uberlandia (UFU)
dc.date.accessioned2021-07-14T10:51:05Z
dc.date.available2021-07-14T10:51:05Z
dc.date.issued2021-06-28
dc.description.abstractThis study aimed to systematically review the literature to assess the effect of preemptive intravenous ibuprofen on pain reduction after lower third molar surgery. Nine databases (PubMed, Scopus, LILACS, SciELO, Embase, Web of Science, Cochrane, Open Gray, and Open Thesis) were used as sources of research, including “grey literature.” The protocol was registered in PROSPERO. Only randomized clinical trials evaluating the effects of preemptive intravenous ibuprofen on pain during and immediately after the extraction of lower third molars were included, without restrictions of year and language. Two reviewers independently performed the study selection, data extraction, and assessment of the risk of bias. The “Joanna Briggs Institute for Randomized Controlled Trials” tool was used to assess the risk of bias. Each study was categorized according to the percentage of positive responses to the questions corresponding to the assessment instrument. The results were measured narratively/descriptively. The initial search resulted in 3,257 records, of which only three studies (n=150 participants) met the eligibility criteria and were included in the qualitative analysis. All studies were published in 2019. The risk of bias ranged from low to moderate. Two studies found significant pain reduction within 48 h after the procedure. In conclusion, the use of preemptive intravenous ibuprofen for extracting third molars reduces pain and analgesic consumption after the surgical procedure.en
dc.description.affiliationProgram de Pos-Graduacao em Odontologia, Faculdade de Odontologia, Universidade Federal de Uberlandia
dc.description.affiliationPrograma de Residencia, Departamento de Cirurgia e Traumatologia Buco-Maxilo-Facial, Faculdade de Odontologia, Universidade Federal de Uberlandia
dc.description.affiliationDepartamento de Odontologia Restauradora, Divisao de Endodontia, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas (UNICAMP)
dc.description.affiliationDepartamento de Farmacologia, Anestesiologia e Terapeutica, Faculdade de Medicina e Odontologia e Centro de Pesquisas Odontologicas Sao Leopoldo Mandic
dc.description.affiliationDepartamento de Cirurgia e Traumatologia Buco-Maxilo-Facial, Faculdade de Odontologia, Universidade Federal de Uberlandia (UFU)
dc.description.affiliationUniversidade Estadual Paulista Julio de Mesquita Filho, Campus Sao Jose dos Campos, Instituto de Ciencia e Tecnologia
dc.description.affiliationArea de Odontologia Preventiva e Social, Faculdade de Odontologia, Universidade Federal de Uberlandia (UFU)
dc.description.affiliationUnespUniversidade Estadual Paulista Julio de Mesquita Filho, Campus Sao Jose dos Campos, Instituto de Ciencia e Tecnologia
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 307808/2018-1
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.6061/clinics/2021/e2780
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 76, p. -, 2021.
dc.identifier.doi10.6061/clinics/2021/e2780
dc.identifier.fileS1807-59322021000100415.pdf
dc.identifier.issn1807-5932
dc.identifier.issn1980-5322
dc.identifier.scieloS1807-59322021000100415
dc.identifier.urihttp://hdl.handle.net/11449/213167
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectIntravenous Ibuprofenen
dc.subjectIbuprofenen
dc.subjectThird Molar Surgeryen
dc.subjectPreemptive Analgesiaen
dc.subjectPainen
dc.subjectPostoperative Painen
dc.titlePreemptive use of intravenous ibuprofen to reduce postoperative pain after lower third molar surgery: a systematic review of randomized controlled trialsen
dc.typeArtigo
unesp.author.orcid0000-0002-4146-478X[1]
unesp.author.orcid0000-0002-8898-9508[2]
unesp.author.orcid0000-0001-8872-2865[3]
unesp.author.orcid0000-0002-3081-1504[4]
unesp.author.orcid0000-0003-4505-2640[5]
unesp.author.orcid0000-0001-6010-8062[6]
unesp.author.orcid0000-0002-4261-4217[7]
unesp.author.orcid0000-0002-7599-0120[8]

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