Synthesis and defect characterization of hybrid ceria nanostructures as a possible novel therapeutic material towards COVID-19 mitigation

Página do item simplificado
dc.contributor.authorRocha, L. S.R.
dc.contributor.authorSimões, A. Z. [UNESP]
dc.contributor.authorMacchi, C.
dc.contributor.authorSomoza, A.
dc.contributor.authorGiulietti, G.
dc.contributor.authorPonce, M. A.
dc.contributor.authorLongo, E.
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionCIFICEN (UNCPBA-CICPBA-CONICET) and Instituto de Física de Materiales Tandil (UNCPBA)
dc.contributor.institutionNational University of Mar del Plata (UNMdP)
dc.date.accessioned2022-05-01T15:13:30Z
dc.date.available2022-05-01T15:13:30Z
dc.date.issued2022-12-01
dc.description.abstractThis study reports the synthesis of hybrid nanostructures composed of cerium dioxide and microcrystalline cellulose prepared by the microwave-assisted hydrothermal route under distinct temperature and pH values. Their structural, morphological and spectroscopic behaviors were investigated by X-Rays Diffraction, Field Emission Gun Scanning Electron Microscopy, High-Resolution Transmission Electron Microscopy, and Fourier-Transform Infrared, Ultraviolet–Visible, Raman and Positron Annihilation Lifetime spectroscopies to evaluate the presence of structural defects and their correlation with the underlying mechanism regarding the biocide activity of the studied material. The samples showed mean crystallite sizes around 10 nm, characterizing the formation of quantum dots unevenly distributed along the cellulose surface with a certain agglomeration degree. The samples presented the characteristic Ce–O vibration close to 450 cm−1 and a second-order mode around 1050 cm−1, which is indicative of distribution of localized energetic levels originated from defective species, essential in the scavenging of reactive oxygen species. Positron spectroscopic studies showed first and second lifetime components ranging between 202–223 ps and 360–373 ps, respectively, revealing the presence of two distinct defective oxygen species, in addition to an increment in the concentration of Ce3+-oxygen vacancy associates as a function of temperature. Therefore, we have successfully synthesized hybrid nanoceria structures with potential multifunctional therapeutic properties to be further evaluated against the COVID-19.en
dc.description.affiliationCenter for Research and Development of Functional Materials Federal University of São Carlos (UFSCar), SP
dc.description.affiliationSchool of Engineering São Paulo State University (UNESP), SP
dc.description.affiliationCIFICEN (UNCPBA-CICPBA-CONICET) and Instituto de Física de Materiales Tandil (UNCPBA), Pinto 399
dc.description.affiliationNational University of Mar del Plata (UNMdP)
dc.description.affiliationUnespSchool of Engineering São Paulo State University (UNESP), SP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdFAPESP: 13/07296-2
dc.description.sponsorshipIdFAPESP: 2018/20590-0
dc.description.sponsorshipIdAgencia Nacional de Promoción Científica y Tecnológica: PICT 2015- 1832
dc.identifierhttp://dx.doi.org/10.1038/s41598-022-07200-9
dc.identifier.citationScientific Reports, v. 12, n. 1, 2022.
dc.identifier.doi10.1038/s41598-022-07200-9
dc.identifier.issn2045-2322
dc.identifier.scopus2-s2.0-85125571705
dc.identifier.urihttp://hdl.handle.net/11449/234215
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.sourceScopus
dc.titleSynthesis and defect characterization of hybrid ceria nanostructures as a possible novel therapeutic material towards COVID-19 mitigationen
dc.typeArtigo
unesp.departmentMateriais e Tecnologia - FEGpt

Arquivos

Coleções

Guaratinguetá - FEG - Faculdade de Engenharia e Ciências