Alpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal area

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dc.contributor.authorCallera, J. C. [UNESP]
dc.contributor.authorSaad, W. A. [UNESP]
dc.contributor.authorCamargo, L. A.A. [UNESP]
dc.contributor.authorMenani, J. V. [UNESP]
dc.contributor.authorRenzi, A. [UNESP]
dc.contributor.authorAbrao-Saad, W. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:54:15Z
dc.date.available2022-04-28T19:54:15Z
dc.date.issued1995-01-01
dc.description.abstractWe studied the effect of the α1- and α2-adrenergic receptors of the lateral hypothalamus (LH on the control of water intake induced by injection of carbachol into the medial septal area (MSA) of adult male Holtzman rats (250-300 g) implanted with chronic stainless steel cannulae into the LH and MSA. The volume of injection was always 1 μl and was injected over a period of 30-60 s. For control, 0.15 M NaCl was used. Clonidine (20 nmol) but not phenylephrine (160 nmol) injected into the LH inhibited water intake induced by injection of carbachol (2 nmol) into the MSA, from 5.4 ± l.2 ml/h to 0.3 ± 0.1 and 3.0 ± 0.9 ml/h, respectively (N = 26). When we injected yohimbine (80 nmol) + clonidine (20 nmol) and prazosin (40 nmol) + clonidine (20 nmol) into the LH, water intake induced by injection of carbachol into the MSA was inhibited from 5.4 ± 1.2 ml/h to 0.8 ± 0.5 and 0.3 ± 0.2 ml/h, respectively (N = 19). Water intake induced by carbachol (2 nmol) injected into the MSA was decreased by previous injection of yohimbine (80 nmol) + phenylephrine (160 nmol) and prazosin (40 nmol) + phenylephrine (160 nmol) from 5.4 ± 1.2 ml/h to 1.0 ± 0.7 and 1.8 ± 0.8 ml/h, respectively (N = 16). The cannula reached both the medial septal area in its medial portion and the lateral hypothalamus. It has been suggested that the different pathways for induction of drinking converge on a final common pathway. Thus, adrenergic stimulation of α2-adrenoceptors of LH can influence this final common pathway.en
dc.description.affiliationDpto. de Ciencias Fisiologicas Faculdade de Odontologia UNESP, Rua Humanita, 1680, 14801-903 Araraquara, SP
dc.description.affiliationUnespDpto. de Ciencias Fisiologicas Faculdade de Odontologia UNESP, Rua Humanita, 1680, 14801-903 Araraquara, SP
dc.format.extent240-245
dc.identifier.citationBrazilian Journal of Medical and Biological Research, v. 28, n. 2, p. 240-245, 1995.
dc.identifier.issn0100-879X
dc.identifier.scopus2-s2.0-0028951248
dc.identifier.urihttp://hdl.handle.net/11449/224001
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.sourceScopus
dc.subjectα1- and α2-adrenoceptors
dc.subjectcholinergic receptors
dc.subjectlateral hypothalamus
dc.subjectseptal area
dc.subjectwater intake
dc.titleAlpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal areaen
dc.typeArtigo

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