Can the aqueous decoction of mango flowers be used as an antiulcer agent?

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dc.contributor.authorLima, Z. P.
dc.contributor.authorSeveri, J. A.
dc.contributor.authorPellizzon, C. H.
dc.contributor.authorBrito, ARMS
dc.contributor.authorSolis, P. N.
dc.contributor.authorCaceres, A.
dc.contributor.authorGiron, L. M.
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorHiruma-Lima, C. A.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniv Panama
dc.contributor.institutionUniv San Carlos
dc.date.accessioned2014-05-20T13:49:46Z
dc.date.available2014-05-20T13:49:46Z
dc.date.issued2006-06-15
dc.description.abstractThis study was designed to determine the effect of Mangifera indica flowers decoction, on the acute and subacute models of induced ulcer in mice and rats. A single oral administration of the aqueous decoction (AD) from M. indica up to a dose of 5 g/kg, p.o. did not produce any signs or symptom of toxicity in the treated animals. The oral pre-treatment with AD (250, 500 and 1000 mg/kg) in rats with gastric lesions induced by ethanol, decreased the gastric lesions from 89.0 +/- 6.71 (control group) to 9.25 +/- 2.75, 4.50 +/- 3.30 and 0, respectively. Pretreatment with AD (250, 500 and 1000 mg/kg) to mice with HCl/ethanol- or stress-induced gastric lesions resulted in a dose-dependent significant decrease of lesion index. In the piroxicam-induced gastric lesions, the gastroprotective effect of AD was reducing with the increase of the AD dose. In the pylorus-ligature, AD (p.o.) significantly decreased the acid output indicating the antisecretory property involved in the gastroprotective effect of M. indica. Treatment with AD during 14 consecutive days significantly accelerated the healing process in subacute gastric ulcer induced by acetic acid in rats. Pretreatment with N-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO-synthase, did not abolish the gastroprotective effects (99% with saline versus 80% With L-NAME) of AD against ethanol-induced gastric lesions. Pretreatment with N-ethylmaleimide (NEM), a blocker of endogenous sulphydryl group, significantly abolished the protective effects of AD against ethanol-induced gastric ulcers (95% with saline versus 47% with NEM). Phytochemical screening showed the presence of steroids, triterpenes, phenolic compounds and flavonoids. Estimation of the global polyphenol content in the AD was performed by Folin-Ciocalteu method and showed approximately 53% of total phenolic on this extract. These findings indicate the potential gastroprotective and ulcer-healing properties of aqueous decoction of M. indica flowers and further support its popular use in gastrointestinal disorders in Caribbean. (c) 2005 Elsevier B.V.. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Biociencias, Dept Fisiol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Quim, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Biociencias, Dept Morfol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Fisiol & Biofis, Inst Biol, Campinas, SP, Brazil
dc.description.affiliationUniv Panama, Coll Pharm, Ctr Invest Farmacognost Flora Panamena, CIFLORPAN, Panama City, Panama
dc.description.affiliationUniv San Carlos, Guatemala City, Guatemala
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Biociencias, Dept Fisiol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Quim, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Biociencias, Dept Morfol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent29-37
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2005.11.032
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier B.V., v. 106, n. 1, p. 29-37, 2006.
dc.identifier.doi10.1016/j.jep.2005.11.032
dc.identifier.issn0378-8741
dc.identifier.lattes0019393779801069
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.orcid0000-0002-4494-4180
dc.identifier.urihttp://hdl.handle.net/11449/17748
dc.identifier.wosWOS:000238297200002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMangifera indicapt
dc.subjectflowerspt
dc.subjectAnacardiaceaept
dc.subjectgastric antiulcerpt
dc.subjecthealing effectpt
dc.titleCan the aqueous decoction of mango flowers be used as an antiulcer agent?en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes0019393779801069[3]
unesp.author.lattes3814504901386844[9]
unesp.author.orcid0000-0002-8645-3777[9]
unesp.author.orcid0000-0003-3032-2556[8]
unesp.author.orcid0000-0002-4494-4180[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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