Comparative mutagenic activity of atmospheric particulate matter from limeira, stockholm, and kyoto

Página do item simplificado
dc.contributor.authorMaselli, Bianca S.
dc.contributor.authorGiron, Macelle C. G.
dc.contributor.authorLim, Hwanmi
dc.contributor.authorBergvall, Christoffer
dc.contributor.authorWesterholm, Roger
dc.contributor.authorDreij, Kristian
dc.contributor.authorWatanabe, Tetsushi
dc.contributor.authorCardoso, Arnaldo A. [UNESP]
dc.contributor.authorUmbuzeiro, Gisela A.
dc.contributor.authorKummrow, Fábio
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionStockholm University
dc.contributor.institutionKarolinska Institutet
dc.contributor.institutionKyoto Pharmaceutical University
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T17:08:41Z
dc.date.available2019-10-06T17:08:41Z
dc.date.issued2019-01-01
dc.description.abstractAtmospheric particulate matter (PM) organic fractions from urban centers are frequently mutagenic for the Salmonella/microsome assay. This mutagenicity is related to both primary and secondary pollutants, and meteorological conditions have great influence on the secondary pollutant's formation. Our objective was to compare the mutagenicity of atmospheric total suspended particulates (TSP) from three cities with marked different meteorological conditions and TSP concentrations: Limeira (Brazil) with 99.0 μg/m3, Stockholm (Sweden) with 6.2 μg/m3, and Kyoto (Japan) with 28.0 μg/m3. For comparison, we used the same batch of filters, sample extraction method, and Salmonella/microsome testing protocol with 11 strains of Salmonella with and without metabolic activation. Samples were collected during winter and pooled into one single extract representing each city. All samples were mutagenic for all tested strains, except for TA102. Based on the strain's selectivity, nitroarenes, polycyclic aromatic hydrocarbons, and aromatic amines play a predominant role in the mutagenicity of these samples. The mutagenic potencies expressed by mass of extracted organic material (EOM; revertants/μg EOM) were similar (~twofold difference) among the cities, despite differences in meteorological conditions and pollution sources. In contrast, the mutagenic potencies expressed by air volume (rev/m3) varied ~20-fold, with Limeira > Kyoto ≈ Stockholm. These results are the first systematic assessment of air mutagenicity from cities on three continents using the same protocols. The results confirm that the mutagenic potency expressed by EOM mass is similar regardless of continent of origin, whereas the mutagenic potency expressed by air volume can vary by orders of magnitude. Environ. Mol. Mutagen. 2019. © 2019 Wiley Periodicals, Inc.en
dc.description.affiliationPharmaceutical Sciences Faculty University of São Paulo (USP)
dc.description.affiliationSchool of Technology State University of Campinas (UNICAMP)
dc.description.affiliationUnit of Analytical Chemistry Department of Environmental Science and Analytical Chemistry Stockholm University
dc.description.affiliationInstitute of Environmental Medicine Karolinska Institutet
dc.description.affiliationDepartment of Public Health Kyoto Pharmaceutical University
dc.description.affiliationInstitute of Chemistry São Paulo State University (UNESP)
dc.description.affiliationInstitute of Environmental Chemical and Pharmaceutical Sciences Federal University of São Paulo (UNIFESP)
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2015/23364-3
dc.format.extent607-616
dc.identifierhttp://dx.doi.org/10.1002/em.22293
dc.identifier.citationEnvironmental and Molecular Mutagenesis, v. 60, n. 7, p. 607-616, 2019.
dc.identifier.doi10.1002/em.22293
dc.identifier.issn1098-2280
dc.identifier.issn0893-6692
dc.identifier.scopus2-s2.0-85065041371
dc.identifier.urihttp://hdl.handle.net/11449/190301
dc.language.isoeng
dc.relation.ispartofEnvironmental and Molecular Mutagenesis
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectaccelerated solvent extraction
dc.subjectmutagenic profiles
dc.subjectSalmonella/microsome microsuspension assay
dc.subjecttotal suspended particles
dc.titleComparative mutagenic activity of atmospheric particulate matter from limeira, stockholm, and kyotoen
dc.typeArtigo
unesp.author.lattes9165109840414837[8]
unesp.author.orcid0000-0003-2977-0108[10]
unesp.author.orcid0000-0003-2046-995X[8]

Arquivos

Coleções

Artigos - Química Analítica - IQ