Impact of metabolic syndrome and its components on bone remodeling in adolescents

Página do item simplificado
dc.contributor.authorDa Silva, Valéria Nóbrega [UNESP]
dc.contributor.authorGoldberg, Tamara Beres Lederer [UNESP]
dc.contributor.authorSilva, Carla Cristiane
dc.contributor.authorKurokawa, Cilmery Suemi [UNESP]
dc.contributor.authorFiorelli, Luciana Nunes Mosca [UNESP]
dc.contributor.authorda Conceição Bisi Rizzo, Anapaula [UNESP]
dc.contributor.authorCorrente, José Eduardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of North Paraná
dc.date.accessioned2022-04-29T08:30:44Z
dc.date.available2022-04-29T08:30:44Z
dc.date.issued2021-07-01
dc.description.abstractIntroduction Osteoporosis and metabolic syndrome (MetS) are diseases that have serious public health consequences, reducing the quality of life of patients and increasing morbidity and mortality, with substantial healthcare expenditures. Objective To evaluate the impact of MetS on bone mineral density (BMD) and biochemical markers of bone formation and resorption in adolescents with excess weight. Method A descriptive and analytical cross-sectional study was performed that evaluated 271 adolescents of both sexes (10 to 16 years). From the total sample, 42 adolescents with excess weight and the presence of MetS (14%) were selected. A further 42 adolescents with excess weight and without MetS were chosen, matched for chronological age, bone age, and pubertal developmental criteria to those with MetS, for each sex. Anthropometric measurements, blood pressure collection, and biochemical tests were performed in all adolescents, as well as evaluation of BMD and the bone biomarkers osteocalcin (OC), bone alkaline phosphatase (BAP), and carboxy-terminal telopeptide (S-CTx). Results The adolescents with excess weight and MetS exhibited significantly lower transformed BMD and concentrations of BAP, OC, and S-CTx compared to the matched group, except for OC in boys. A negative and significant correlation was observed between total body BMD and BAP (r = -0.55568; p = 0.005), OC (r = -0.81760; p = < .000), and S-CTx (r = -0.53838; p = 0.011) in girls. Conclusion Metabolic syndrome may be associated with reduced bone mineral density and biochemical markers of bone formation and resorption in adolescents with excess weight.en
dc.description.affiliationDepartment of Pediatrics Postgraduate Program in Tocogynecology Discipline of Adolescent Medicine Botucatu Medical School UNESP São Paulo State University, SP
dc.description.affiliationDepartment of Physical Education University of North Paraná, Paraná
dc.description.affiliationDepartment of Pediatrics Clinical and Experimental Pediatric Research Center Botucatu Medical School UNESP São Paulo State University, SP
dc.description.affiliationDepartment of Statistics Biosciences UNESP São Paulo State University, SP
dc.description.affiliationUnespDepartment of Pediatrics Postgraduate Program in Tocogynecology Discipline of Adolescent Medicine Botucatu Medical School UNESP São Paulo State University, SP
dc.description.affiliationUnespDepartment of Pediatrics Clinical and Experimental Pediatric Research Center Botucatu Medical School UNESP São Paulo State University, SP
dc.description.affiliationUnespDepartment of Statistics Biosciences UNESP São Paulo State University, SP
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0253892
dc.identifier.citationPLoS ONE, v. 16, n. 7 July, 2021.
dc.identifier.doi10.1371/journal.pone.0253892
dc.identifier.issn1932-6203
dc.identifier.scopus2-s2.0-85110327513
dc.identifier.urihttp://hdl.handle.net/11449/229149
dc.language.isoeng
dc.relation.ispartofPLoS ONE
dc.sourceScopus
dc.titleImpact of metabolic syndrome and its components on bone remodeling in adolescentsen
dc.typeArtigo

Arquivos

Coleções

Artigos - Ginecologia e Obstetrícia - FMB
Artigos - Pediatria - FMB