Mannose-binding lectin gene polymorphism and risk factors for cardiovascular disease in postmenopausal women

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dc.contributor.authorOrsatti, Claudio Lera [UNESP]
dc.contributor.authorNahás, Eliana Aguiar Petri [UNESP]
dc.contributor.authorNahas-Net, Jorge [UNESP]
dc.contributor.authorOrsatti, Fabio Lera
dc.contributor.authorLinhares, Iara Moreno
dc.contributor.authorWitkin, Steven Sol [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Hlth Sci UFTM
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionWeill Cornell Med Coll
dc.date.accessioned2015-03-18T15:53:42Z
dc.date.available2015-03-18T15:53:42Z
dc.date.issued2014-09-01
dc.description.abstractBackground: Inflammatory responses may be altered in postmenopausal women and predispose to cardiovascular disease (CVD). Genetic factors can also influence susceptibility to CVD. Mannose-binding lectin (MBL) is a component of the innate immune system and an activator of the complement cascade. We evaluated the association of genetic polymorphism of MBL (MBL2) on risk factors for CVD in postmenopausal women. Methods: In this cross-sectional study, 311 Brazilian women (age >= 45 years and amenorrhea >= 12 months) were included. Exclusion criteria: presence of previous or current CVD, insulin dependent diabetes, chronic kidney disease, autoimmune diseases and cancer. Clinical, anthropometric and biochemical assessments were performed to evaluate the cardiovascular risk factors. DNA was extracted from buccal cell and polymorphisms at codons 54 and 57 in the MBL2 were determined by polymerase chain reaction (PCR). For statistical analysis, the chi-square and logistic regression (odds ratio, OR) were used. Results: The presence of the polymorphic allele for codon 54 was found in 25.8% of women (A/B = 22.6%, B/B = 3.2%) and for codon 57 in 12.2% (A/C = 10.8%, C/C = 1.4%). The polymorphism at codon 54 was significantly associated with the presence of hypertension (OR 0.55, 95% CI 0.31-0.99, p = 0.044) and insulin resistance assessed by HOMA-IR (OR 0.46, 95% CI 0.24-0.91, p = 0.025). No significant associations were observed between the polymorphism at codon 57 with risk factors for CVD. Conclusion: In postmenopausal women, the polymorphism at cation 54 of the MBL2 was associated with lower risk for hypertension and insulin resistance that are important risk factors for CVD. (C) 2014 Published by Elsevier Ltd.en
dc.description.affiliationSao Paulo State Univ UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationInst Hlth Sci UFTM, Dept Sports Sci, Uberaba, MG, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Gynecol & Obstet, Sao Paulo, Brazil
dc.description.affiliationWeill Cornell Med Coll, Div Immunol & Infect Dis, Dept Obstet & Gynecol, New York, NY USA
dc.description.affiliationUnespSao Paulo State Univ UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 09/14884-2
dc.description.sponsorshipIdFAPESP: 09/18256-6
dc.format.extent23-27
dc.identifierhttp://dx.doi.org/10.1016/j.molimm.2014.05.003
dc.identifier.citationMolecular Immunology. Oxford: Pergamon-elsevier Science Ltd, v. 61, n. 1, p. 23-27, 2014.
dc.identifier.doi10.1016/j.molimm.2014.05.003
dc.identifier.issn0161-5890
dc.identifier.lattes4155170574788417
dc.identifier.urihttp://hdl.handle.net/11449/116670
dc.identifier.wosWOS:000337872700004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMolecular Immunology
dc.relation.ispartofjcr3.188
dc.relation.ispartofsjr1,352
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMannose-binding lectinen
dc.subjectPostmenopausal womenen
dc.subjectCardiovascular diseaseen
dc.subjectPolymorphismen
dc.titleMannose-binding lectin gene polymorphism and risk factors for cardiovascular disease in postmenopausal womenen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes4155170574788417
unesp.author.orcid0000-0001-9161-5737[4]
unesp.author.orcid0000-0002-6258-2646[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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