Expression of odontogenic ameloblast-associated protein, amelotin, ameloblastin, and amelogenin in odontogenic tumors: immunohistochemical analysis and pathogenetic considerations

Página do item simplificado
dc.contributor.authorCrivelini, Marcelo Macedo [UNESP]
dc.contributor.authorFelipini, Renata Callestini [UNESP]
dc.contributor.authorMiyahara, Glauco Issamu [UNESP]
dc.contributor.authorOrsini Machado de Sousa, Suzana Cantanhede
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2013-09-30T18:31:11Z
dc.date.accessioned2014-05-20T13:44:39Z
dc.date.available2013-09-30T18:31:11Z
dc.date.available2014-05-20T13:44:39Z
dc.date.issued2012-03-01
dc.description.abstractScreening for expression of amelogenesis-related proteins represents a powerful molecular approach to characterize odontogenic tumors and investigate their pathogenesis. In this study, we have examined the presence and distribution of odontogenic ameloblast-associated protein (ODAM), amelotin (AMTN), ameloblastin (AMBN), and amelogenin (AMEL) by immunohistochemistry in samples of adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), developing odontoma, ameloblastoma, calcifying cystic odontogenic tumor (CCOT), ameloblastic fibroma (AF), myxoma, odontogenic fibroma (OF), and reduced enamel epithelia (REE). Positive results were obtained in those tumors with epithelial component, except for AF, OF, and ameloblastoma. ODAM was found around mineralized structures (dystrophic calcifications) and CEOT's amyloid, whereas AMTN stained the eosinophilic material of AOTs. The CCOT transitory cells to ghost cells were strongly positive with all proteins except AMEL, and the REE as well as odontomas showed immunoexpression for ODAM, AMTN, AMBN, and AMEL similar to those found in normal rat tooth germs. Based on these results, some histopathogenetic theories were formulated. J Oral Pathol Med (2012) 41: 272-280en
dc.description.affiliationUnesp Univ Estadual Paulista, Dept Pathol & Clin Propaedeut, Aracatuba Sch Dent, BR-6015050 Aracatuba, SP, Brazil
dc.description.affiliationUsp Univ São Paulo, Dept Stomatol, Sch Dent, São Paulo, Brazil
dc.description.affiliationUnespUnesp Univ Estadual Paulista, Dept Pathol & Clin Propaedeut, Aracatuba Sch Dent, BR-6015050 Aracatuba, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipCanadian Institutes of Health Research (CIHR)
dc.description.sponsorshipIdCAPES: 3156/06-0
dc.format.extent272-280
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0714.2011.01079.x
dc.identifier.citationJournal of Oral Pathology & Medicine. Malden: Wiley-blackwell, v. 41, n. 3, p. 272-280, 2012.
dc.identifier.doi10.1111/j.1600-0714.2011.01079.x
dc.identifier.issn0904-2512
dc.identifier.lattes9544257482512671
dc.identifier.lattes6207099947394016
dc.identifier.lattes4146341015030248
dc.identifier.urihttp://hdl.handle.net/11449/15657
dc.identifier.wosWOS:000300935200012
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.relation.ispartofjcr2.237
dc.relation.ispartofsjr0,791
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdental enamel proteinsen
dc.subjectimmunohistochemistryen
dc.subjectodontogenic ameloblast-associated proteinen
dc.subjectodontogenic tumoren
dc.titleExpression of odontogenic ameloblast-associated protein, amelotin, ameloblastin, and amelogenin in odontogenic tumors: immunohistochemical analysis and pathogenetic considerationsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes9544257482512671
unesp.author.lattes4146341015030248
unesp.author.lattes6207099947394016[2]
unesp.author.orcid0000-0002-5748-9412[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Patologia e Propedêutica Clínica - FOA