Intestinal Microbiota and miRNA in IBD: A Narrative Review about Discoveries and Perspectives for the Future

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dc.contributor.authorOliveira, Ellen Cristina Souza de [UNESP]
dc.contributor.authorQuaglio, Ana Elisa Valencise [UNESP]
dc.contributor.authorMagro, Daniéla Oliveira
dc.contributor.authorDi Stasi, Luiz Claudio [UNESP]
dc.contributor.authorSassaki, Ligia Yukie [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2023-07-29T13:53:18Z
dc.date.available2023-07-29T13:53:18Z
dc.date.issued2023-04-01
dc.description.abstractInflammatory bowel disease (IBD) includes Crohn’s disease (CD) and ulcerative colitis (UC) and comprises a chronic gastrointestinal tract disorder characterized by hyperactive and dysregulated immune responses to environmental factors, including gut microbiota and dietary components. An imbalance of the intestinal microbiota may contribute to the development and/or worsening of the inflammatory process. MicroRNAs (miRNAs) have been associated with various physiological processes, such as cell development and proliferation, apoptosis, and cancer. In addition, they play an important role in inflammatory processes, acting in the regulation of pro- and anti-inflammatory pathways. Differences in the profiles of miRNAs may represent a useful tool in the diagnosis of UC and CD and as a prognostic marker in both diseases. The relationship between miRNAs and the intestinal microbiota is not completely elucidated, but recently this topic has gained prominence and has become the target of several studies that demonstrate the role of miRNAs in the modulation of the intestinal microbiota and induction of dysbiosis; the microbiota, in turn, can regulate the expression of miRNAs and, consequently, alter the intestinal homeostasis. Therefore, this review aims to describe the interaction between the intestinal microbiota and miRNAs in IBD, recent discoveries, and perspectives for the future.en
dc.description.affiliationDepartment of Internal Medicine Medical School Sao Paulo State University (UNESP), Campus Botucatu
dc.description.affiliationLaboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTec) Department of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University (UNESP), Campus Botucatu
dc.description.affiliationDepartment of Surgery Faculty of Medical Sciences State University of Campinas (UNICAMP)
dc.description.affiliationUnespDepartment of Internal Medicine Medical School Sao Paulo State University (UNESP), Campus Botucatu
dc.description.affiliationUnespLaboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTec) Department of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University (UNESP), Campus Botucatu
dc.identifierhttp://dx.doi.org/10.3390/ijms24087176
dc.identifier.citationInternational Journal of Molecular Sciences, v. 24, n. 8, 2023.
dc.identifier.doi10.3390/ijms24087176
dc.identifier.issn1422-0067
dc.identifier.issn1661-6596
dc.identifier.scopus2-s2.0-85156214258
dc.identifier.urihttp://hdl.handle.net/11449/248771
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.sourceScopus
dc.subjectCrohn’s disease
dc.subjectdysbiosis
dc.subjectinflammatory bowel
dc.subjectintestinal microbiota
dc.subjectmicroRNA
dc.subjectulcerative colitis
dc.titleIntestinal Microbiota and miRNA in IBD: A Narrative Review about Discoveries and Perspectives for the Futureen
dc.typeResenha
unesp.author.orcid0000-0002-8180-6254[3]
unesp.author.orcid0000-0002-7319-8906[5]

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