Commissural nucleus of the solitary tract lesions reduce food intake and body weight gain in rats

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dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.authorTalman, William T.
dc.contributor.authorJohnson, Alan Kim
dc.contributor.institutionVeterans Affairs Medical Center
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Iowa
dc.date.accessioned2014-05-27T11:18:07Z
dc.date.available2014-05-27T11:18:07Z
dc.date.issued1996-11-18
dc.description.abstractThis study investigated the effects of an electrolytic lesion of the commissural subnucleus of the nucleus of the solitary tract (commNTS) on bodyweight, daily food and water intake, and plasma glucose and insulin in rats. In the first 6 days following brain surgery, commNTS lesioned rats reduced daily food intake by 80% compared to rats with sham lesions. After this period rats with lesions of commNTS started recovering food intake, but intake remained significantly reduced until the 12th day after surgery. A reduction in body weight was observed 4 days after surgery and reached a maximum on the 12th day. After this, a partial recovery of body weight was observed, but weight remained significantly reduced compared to weights of rats with sham lesions through the conclusion of the study. Food intake and body weight gain in other rats with partial lesions of the commNTS or with lesions outside the commNTS did not differ from rats with sham lesions with regard to those variables. Daily water intake and plasma glucose and insulin were not changed by the commNTS lesions. These results suggest that commNTS is involved with mechanisms that control food intake and body weight in rats.en
dc.description.affiliationDepts. of Psychol., Pharmacology University of Iowa Veterans Affairs Medical Center, Iowa City, IA 52242
dc.description.affiliationDepartment of Physiology School of Dentistry Paulista State University, Araraquara SP 14800
dc.description.affiliationDept. of Psychology and Pharmacology University of Iowa 11 Seashore Hall E., Iowa City, IA 52242-1407
dc.description.affiliationUnespDepartment of Physiology School of Dentistry Paulista State University, Araraquara SP 14800
dc.format.extent102-108
dc.identifierhttp://dx.doi.org/10.1016/S0006-8993(96)00850-5
dc.identifier.citationBrain Research, v. 740, n. 1-2, p. 102-108, 1996.
dc.identifier.doi10.1016/S0006-8993(96)00850-5
dc.identifier.issn0006-8993
dc.identifier.lattes1023597870118105
dc.identifier.lattes4544450092427426
dc.identifier.scopus2-s2.0-0030592752
dc.identifier.urihttp://hdl.handle.net/11449/64876
dc.identifier.wosWOS:A1996VX99400013
dc.language.isoeng
dc.relation.ispartofBrain Research
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,404
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectfood ingestion
dc.subjectglucose
dc.subjecthindbrain
dc.subjectinsulin
dc.subjectsatiety
dc.subjectwater intake
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectbody weight
dc.subjectbrain injury
dc.subjectcontrolled study
dc.subjectfluid intake
dc.subjectfood intake
dc.subjecthistology
dc.subjectpriority journal
dc.subjectsolitary tract nucleus
dc.subjectNon-programmatic
dc.subjectBody Weight
dc.subjectDrinking
dc.subjectEating
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectSolitary Nucleus
dc.titleCommissural nucleus of the solitary tract lesions reduce food intake and body weight gain in ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes1023597870118105
unesp.author.lattes4544450092427426[2]
unesp.author.orcid0000-0002-1395-4036[2]
unesp.author.orcid0000-0003-1167-4441[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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